Titre
Acute cerebral ischaemia: concurrent changes in cerebral blood flow, energy metabolites, pH, and lactate measured with hydrogen clearance and 31P and 1H nuclear magnetic resonance spectroscopy. I. Methodology.
Type
article
Institution
Externe
Périodique
Auteur(s)
Gadian, D.G.
Auteure/Auteur
Frackowiak, R.S.
Auteure/Auteur
Crockard, H.A.
Auteure/Auteur
Proctor, E.
Auteure/Auteur
Allen, K.
Auteure/Auteur
Williams, S.R.
Auteure/Auteur
Russell, R.W.
Auteure/Auteur
Liens vers les personnes
ISSN
0271-678X
Statut éditorial
Publié
Date de publication
1987
Volume
7
Numéro
2
Première page
199
Dernière page/numéro d’article
206
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
CBF has been measured with the hydrogen clearance technique in the two cerebral hemispheres of the gerbil under halothane anaesthesia. This has been correlated with changes in local pH, tissue lactate, and phosphorus energy metabolites measured in the same animals with 1H and 31P nuclear magnetic resonance (NMR) spectroscopy. The NMR measurements were made with two surface coils, one on each hemisphere. This article describes the experimental details and shows that in acute unilateral or bilateral forebrain ischaemia metabolic changes can be monitored by NMR with no significant interhemispheric cross talk. The metabolic effects of reperfusion are also shown. The model allows the definition of the time course of the metabolic consequences of regional ischaemia and reperfusion in individual laboratory animals.
PID Serval
serval:BIB_1F5D05908230
PMID
Open Access
Oui
Date de création
2011-10-08T13:37:03.668Z
Date de création dans IRIS
2025-05-20T15:21:15Z