Titre
MRI is the most commonly used imaging modality for HCC screening at a tertiary care transplant center.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Hernandez-Meza, G.
Auteure/Auteur
Violi, N.V.
Auteure/Auteur
Said, D.
Auteure/Auteur
Novogrodsky, E.
Auteure/Auteur
Villavisanis, D.
Auteure/Auteur
Maron, S.Z.
Auteure/Auteur
Frere, J.
Auteure/Auteur
Schiano, T.D.
Auteure/Auteur
Friedman, S.
Auteure/Auteur
Boffetta, P.
Auteure/Auteur
Branch, A.
Auteure/Auteur
Taouli, B.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
2366-0058
Statut éditorial
Publié
Date de publication
2021-11
Volume
46
Numéro
11
Première page
5142
Dernière page/numéro d’article
5151
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
In this study, we describe the patterns of hepatocellular carcinoma (HCC) screening with imaging and factors associated with imaging modality selection in a tertiary care transplant center.
This was a retrospective study where all adult patients with cirrhosis and/or chronic hepatitis B virus infection referred for HCC screening with ultrasound (US), CT or MRI were identified during 2017. The association between imaging methods, demographic/clinical data were analyzed by uni- and multivariate analysis.
A total of 1437 patients were included (median age 61y, 59% male, median BMI 27.5 kg/m <sup>2</sup> , median AFP 3.4 ng/mL, 37% with HCV and 87% with cirrhosis). Index screening imaging method utilization included MRI (51%), US (33%) and CT (16%). Use of US as the index imaging modality for screening was significantly associated with race/ethnicity [Odds Ratio (OR) 1.71-2.01, all p < 0.05] in multivariate analysis. Presence of cirrhosis (OR 0.29, p < 0.001) and referral by a hepatologist (OR 0.23, p < 0.001) were associated with screening with MRI in the multivariate analysis; while gender, age, BMI, etiology and income at ZIP code of residence were not significantly associated with imaging modality selection. HCC was observed in 62 patients (prevalence 4.3%). Rate of HCC detection was significantly higher with MRI vs US (5.9% vs. 1.5%, p = 0.001).
MRI was the most frequently used modality (> 50%) for HCC screening in our tertiary care center, in contrast with the current practice guidelines. Race/ethnicity, cirrhosis and referral by a hepatologist were associated with the imaging method used for HCC screening.
This was a retrospective study where all adult patients with cirrhosis and/or chronic hepatitis B virus infection referred for HCC screening with ultrasound (US), CT or MRI were identified during 2017. The association between imaging methods, demographic/clinical data were analyzed by uni- and multivariate analysis.
A total of 1437 patients were included (median age 61y, 59% male, median BMI 27.5 kg/m <sup>2</sup> , median AFP 3.4 ng/mL, 37% with HCV and 87% with cirrhosis). Index screening imaging method utilization included MRI (51%), US (33%) and CT (16%). Use of US as the index imaging modality for screening was significantly associated with race/ethnicity [Odds Ratio (OR) 1.71-2.01, all p < 0.05] in multivariate analysis. Presence of cirrhosis (OR 0.29, p < 0.001) and referral by a hepatologist (OR 0.23, p < 0.001) were associated with screening with MRI in the multivariate analysis; while gender, age, BMI, etiology and income at ZIP code of residence were not significantly associated with imaging modality selection. HCC was observed in 62 patients (prevalence 4.3%). Rate of HCC detection was significantly higher with MRI vs US (5.9% vs. 1.5%, p = 0.001).
MRI was the most frequently used modality (> 50%) for HCC screening in our tertiary care center, in contrast with the current practice guidelines. Race/ethnicity, cirrhosis and referral by a hepatologist were associated with the imaging method used for HCC screening.
PID Serval
serval:BIB_FC4046AC5270
PMID
Date de création
2021-07-26T07:34:30.748Z
Date de création dans IRIS
2025-05-21T05:18:04Z
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