Titre
Long term anti-SARS-CoV-2 antibody kinetics and correlate of protection against Omicron BA.1/BA.2 infection.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Perez-Saez, J.
Auteure/Auteur
Zaballa, M.E.
Auteure/Auteur
Lamour, J.
Auteure/Auteur
Yerly, S.
Auteure/Auteur
Dubos, R.
Auteure/Auteur
Courvoisier, D.S.
Auteure/Auteur
Villers, J.
Auteure/Auteur
Balavoine, J.F.
Auteure/Auteur
Pittet, D.
Auteure/Auteur
Kherad, O.
Auteure/Auteur
Vuilleumier, N.
Auteure/Auteur
Kaiser, L.
Auteure/Auteur
Guessous, I.
Auteure/Auteur
Stringhini, S.
Auteure/Auteur
Azman, A.S.
Auteure/Auteur
Éditeur(s)
Arm-Vernez I, Bachmann D. Bal A. Barbe R. P. Baysson H. Berthelot J. Bryand-Rumley G. Chappuis F. Collombet P. Coudurier-Boeuf S. de Mestral C. D'ippolito P. Dumont R. El Merjani N. Flahault A. Francioli N. Graindorge C. Harnal S. Hurst S. Lescuyer P. L'Huillier A. G. Loizeau A. J. Lorthe E. Martinez C. Metral-Boffod L. Nehme M. Noel N. Pennacchio F. Posfay-Barbe K. M. Poulain G. Pugin C. Pullen N. Richard V. Rochat D. Samir K. Ramirez H. S. Satin E. Schaller P. Schrempft S. Semaani C. Testini S. Urrutia-Rivas D. Verolet C. Vetter P. Violot G. Wisniak A.
Contributrices/contributeurs
Arm-Vernez, I.
Bachmann, D.
Bal, A.
Barbe, R.P.
Baysson, H.
Berthelot, J.
Bryand-Rumley, G.
Chappuis, F.
Collombet, P.
Coudurier-Boeuf, S.
de Mestral, C.
D'ippolito, P.
Dumont, R.
El Merjani, N.
Flahault, A.
Francioli, N.
Graindorge, C.
Harnal, S.
Hurst, S.
Lescuyer, P.
L'Huillier, A.G.
Loizeau, A.J.
Lorthe, E.
Martinez, C.
Metral-Boffod, L.
Nehme, M.
Noël, N.
Pennacchio, F.
Posfay-Barbe, K.M.
Poulain, G.
Pugin, C.
Pullen, N.
Richard, V.
Rochat, D.
Samir, K.
Ramirez, H.S.
Satin, E.
Schaller, P.
Schrempft, S.
Semaani, C.
Testini, S.
Urrutia-Rivas, D.
Verolet, C.
Vetter, P.
Violot, G.
Wisniak, A.
Groupes de travail
Specchio-COVID19 study group
Liens vers les personnes
Liens vers les unités
ISSN
2041-1723
Statut éditorial
Publié
Date de publication
2023-05-26
Volume
14
Numéro
1
Première page
3032
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Publication Status: epublish
Résumé
Binding antibody levels against SARS-CoV-2 have shown to be correlates of protection against infection with pre-Omicron lineages. This has been challenged by the emergence of immune-evasive variants, notably the Omicron sublineages, in an evolving immune landscape with high levels of cumulative incidence and vaccination coverage. This in turn limits the use of widely available commercial high-throughput methods to quantify binding antibodies as a tool to monitor protection at the population-level. Here we show that anti-Spike RBD antibody levels, as quantified by the immunoassay used in this study, are an indirect correlate of protection against Omicron BA.1/BA.2 for individuals previously infected by SARS-CoV-2. Leveraging repeated serological measurements between April 2020 and December 2021 on 1083 participants of a population-based cohort in Geneva, Switzerland, and using antibody kinetic modeling, we found up to a three-fold reduction in the hazard of having a documented positive SARS-CoV-2 infection during the Omicron BA.1/BA.2 wave for anti-S antibody levels above 800 IU/mL (HR 0.30, 95% CI 0.22-0.41). However, we did not detect a reduction in hazard among uninfected participants. These results provide reassuring insights into the continued interpretation of SARS-CoV-2 binding antibody measurements as an independent marker of protection at both the individual and population levels.
PID Serval
serval:BIB_73C166DF5907
PMID
Open Access
Oui
Date de création
2023-05-31T07:39:30.992Z
Date de création dans IRIS
2025-05-20T23:04:11Z
Fichier(s)![Vignette d'image]()
En cours de chargement...
Nom
37230973_BIB_73C166DF5907.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by/4.0
Taille
2.53 MB
Format
Adobe PDF
PID Serval
serval:BIB_73C166DF5907.P001
URN
urn:nbn:ch:serval-BIB_73C166DF59071
Somme de contrôle
(MD5):3d578974cc66bdbbfb207d42c9cc5c66