Titre
Mycobacterium leprae-reactive T-cell clones isolated from polar lepromatous and tuberculoid leprosy patients.
Type
article
Institution
Externe
Périodique
Auteur(s)
Launois, P.
Auteure/Auteur
Shankar, P.
Auteure/Auteur
Wallach, D.
Auteure/Auteur
Flageul, B.
Auteure/Auteur
Cottenot, F.
Auteure/Auteur
Bach, M.A.
Auteure/Auteur
Liens vers les personnes
ISSN
0769-2625
Statut éditorial
Publié
Date de publication
1987
Volume
138
Numéro
5
Première page
723
Dernière page/numéro d’article
735
Langue
anglais
Résumé
T-cell clones capable of mounting a proliferative response to Mycobacterium leprae were obtained in three leprosy patients (two polar lepromatous and one polar tuberculoid) either from M. leprae-activated or from protein-purified derivative-activated polyclonal T lymphoblasts. All these clones expressed the CD4 surface marker. Some of them proliferated to the antigen only in the presence of interleukin-2. A majority expressed cross-reactive responses to other mycobacteria. Clones obtained from the lepromatous patients did not differ in any of these features from those obtained from the tuberculoid patient. M. leprae-reactive clones obtained from one lepromatous patient displayed strong antigen-specific cytotoxicity toward autologous antigen-coated target cells. This phenomenon was not observed for any clone of the other lepromatous patient and was seen only for one clone in the tuberculoid patient.
PID Serval
serval:BIB_AB69ECC8C099
PMID
Date de création
2008-01-28T10:06:10.285Z
Date de création dans IRIS
2025-05-20T21:40:54Z