Titre
Preparing for Selective Inhibition within Frontostriatal Loops.
Type
article
Institution
Externe
Périodique
Auteur(s)
Smittenaar, P.
Auteure/Auteur
Guitart-Masip, M.
Auteure/Auteur
Lutti, A.
Auteure/Auteur
Dolan, R.J.
Auteure/Auteur
Liens vers les personnes
ISSN
1529-2401
Statut éditorial
Publié
Date de publication
2013
Volume
33
Numéro
46
Première page
18087
Dernière page/numéro d’article
18097
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
Action inhibition can globally prevent all motor output or selectively cancel specific actions during concurrent motor output. Here we examine the behavioral and neural basis of selective inhibition focusing on the role of preparation. In 18 healthy human participants we manipulated the extent to which they could prepare for selective inhibition by providing or withholding information on what actions might need to be stopped. We show that, on average, information improves both speed and selectivity of inhibition. Functional magnetic resonance imaging data show that preparation for selective inhibition engages the inferior frontal gyrus, supplementary motor area, and striatum. Examining interindividual differences, we find the benefit of proactive control to speed and selectivity of inhibition trade off against each other, such that an improvement in stopping speed leads to a deterioration of selectivity of inhibition, and vice versa. This trade-off is implemented through engagement of the dorsolateral prefrontal cortex and putamen. Our results suggest proactive selective inhibition is implemented within frontostriatal structures, and we provide evidence that a speed-selectivity trade-off might underlie a range of findings reported previously.
PID Serval
serval:BIB_C02221EEE938
PMID
Open Access
Oui
Date de création
2013-12-11T16:58:09.785Z
Date de création dans IRIS
2025-05-21T00:46:52Z