Titre
Electrical source imaging for presurgical focus localization in epilepsy patients with normal MRI.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Brodbeck, Verena
Auteure/Auteur
Spinelli, Laurent
Auteure/Auteur
Lascano Agustina, M.
Auteure/Auteur
Pollo, Claudio
Auteure/Auteur
Schaller, Karl
Auteure/Auteur
Vargas Maria, I.
Auteure/Auteur
Wissmeyer, Michael
Auteure/Auteur
Michel Christoph, M.
Auteure/Auteur
Seeck, Margitta
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1528-1167[electronic], 0013-9580[linking]
Statut éditorial
Publié
Date de publication
2010
Volume
51
Numéro
4
Première page
583
Dernière page/numéro d’article
591
Langue
anglais
Résumé
PURPOSE: Patients with magnetic resonance (MR)-negative focal epilepsy (MRN-E) have less favorable surgical outcomes (between 40% and 70%) compared to those in whom an MRI lesion guides the site of surgical intervention (60-90%). Patients with extratemporal MRN-E have the worst outcome (around 50% chance of seizure freedom). We studied whether electroencephalography (EEG) source imaging (ESI) of interictal epileptic activity can contribute to the identification of the epileptic focus in patients with normal MRI. METHODS: We carried out ESI in 10 operated patients with nonlesional MRI and a postsurgical follow-up of at least 1 year. Five of the 10 patients had extratemporal lobe epilepsy. Evaluation comprised surface and intracranial EEG monitoring of ictal and interictal events, structural MRI, [(18)F]fluorodeoxyglucose positron emission tomography (FDG-PET), ictal and interictal perfusion single photon emission computed tomography (SPECT) scans. Eight of the 10 patients also underwent intracranial monitoring. RESULTS: ESI correctly localized the epileptic focus within the resection margins in 8 of 10 patients, 9 of whom experienced favorable postsurgical outcomes. DISCUSSION: The results highlight the diagnostic value of ESI and encourage broadening its application to patients with MRN-E. If the surface EEG contains fairly localized spikes, ESI contributes to the presurgical decision process.
PID Serval
serval:BIB_F86AA71ADA59
PMID
Date de création
2010-04-22T07:09:49.192Z
Date de création dans IRIS
2025-05-21T05:28:24Z