Titre
Essential role of the glycosyltransferase sxc/Ogt in polycomb repression.
Type
article
Institution
Externe
Périodique
Auteur(s)
Gambetta, M.C.
Auteure/Auteur
Oktaba, K.
Auteure/Auteur
Müller, J.
Auteure/Auteur
Liens vers les personnes
ISSN
1095-9203
Statut éditorial
Publié
Date de publication
2009-07-03
Volume
325
Numéro
5936
Première page
93
Dernière page/numéro d’article
96
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
Polycomb group proteins are conserved transcriptional repressors that control animal and plant development. Here, we found that the Drosophila Polycomb group gene super sex combs (sxc) encodes Ogt, the highly conserved glycosyltransferase that catalyzes the addition of N-acetylglucosamine (GlcNAc) to proteins in animals and plants. Genome-wide profiling in Drosophila revealed that GlcNAc-modified proteins are highly enriched at Polycomb response elements. Among different Polycomb group proteins, Polyhomeotic is glycosylated by Sxc/Ogt in vivo. sxc/Ogt-null mutants lacked O-linked GlcNAcylation and failed to maintain Polycomb transcriptional repression even though Polycomb group protein complexes were bound at their target sites. Polycomb repression appears to be a critical function of Sxc/Ogt in Drosophila and may be mediated by the glycosylation of Polyhomeotic.
Sujets
PID Serval
serval:BIB_408AF6B7F87E
PMID
Date de création
2018-07-19T08:56:56.652Z
Date de création dans IRIS
2025-05-20T14:58:57Z