Titre
Steroid hormone regulation of C. elegans and Drosophila aging and life history.
Type
synthèse (review)
Institution
Externe
Périodique
Auteur(s)
Gáliková, M.
Auteure/Auteur
Klepsatel, P.
Auteure/Auteur
Senti, G.
Auteure/Auteur
Flatt, T.
Auteure/Auteur
Liens vers les personnes
ISSN
1873-6815
Statut éditorial
Publié
Date de publication
2011
Volume
46
Numéro
2-3
Première page
141
Dernière page/numéro d’article
147
Peer-reviewed
Oui
Langue
anglais
Résumé
In the last two decades it has become clear that hormones and gene mutations in endocrine signaling pathways can exert major effects on lifespan and related life history traits in worms, flies, mice, and other organisms. While most of this research has focused on insulin/insulin-like growth factor-1 signaling, a peptide hormone pathway, recent work has shown that also lipophilic hormones play an important role in modulating lifespan and other life history traits. Here we review how steroid hormones, a particular group of lipophilic hormones, affect life history traits in the nematode worm (Caenorhabditis elegans) and the fruit fly (Drosophila melanogaster), with a particular focus on longevity. Interestingly, a comparison suggests that parallel endocrine principles might be at work in worms and flies in these species and that steroid hormones interact with the gonad to affect lifespan.
PID Serval
serval:BIB_F01EE982AA8C
PMID
Date de création
2013-01-28T10:47:29.662Z
Date de création dans IRIS
2025-05-21T05:40:16Z