Titre
Clinical significance and comorbidity of subthreshold depression and anxiety in the community
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Preisig, Martin
Auteure/Auteur
Merikangas Kathleen, R.
Auteure/Auteur
Angst, Jules
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0001-690X
Statut éditorial
Publié
Date de publication
2001
Volume
104
Numéro
2
Première page
96
Dernière page/numéro d’article
103
Peer-reviewed
Oui
Langue
anglais
Notes
SAPHIRID:48279
Résumé
OBJECTIVE: The study tests the hypothesis that intramodal visual binding is disturbed in schizophrenia and should be detectable in all illness stages as a stable trait marker. METHOD: Three groups of patients (rehospitalized chronic schizophrenic, first admitted schizophrenic and schizotypal patients believed to be suffering from a pre-schizophrenic prodrome) and a group of normal control subjects were tested on three tasks targeting visual 'binding' abilities (Muller-Lyer's illusion and two figure detection tasks) in addition to control parameters such as reaction time, visual selective attention, Raven's test and two conventional cortical tasks of spatial working memory (SWM) and a global local test. RESULTS: Chronic patients had a decreased performance on the binding tests. Unexpectedly, the prodromal group exhibited an enhanced Gestalt extraction on these tests compared both to schizophrenic patients and to healthy subjects. Furthermore, chronic schizophrenia was associated with a poor performance on cortical tests of SWM, global local and on Raven. This association appears to be mediated by or linked to the chronicity of the illness. CONCLUSION: The study confirms a variety of neurocognitive deficits in schizophrenia which, however, in this sample seem to be linked to chronicity of illness. However, certain aspects of visual processing concerned with Gestalt extraction deserve attention as potential vulnerability- or prodrome- indicators. The initial hypothesis of the study is rejected
PID Serval
serval:BIB_8FF9661D2B38
PMID
Open Access
Oui
Date de création
2008-03-13T07:39:45.516Z
Date de création dans IRIS
2025-05-21T02:12:44Z