Titre
Prior contacts with the 2000-2003 seasonal vaccines extends the 2009 pandemic A/H1N1 vaccine-specific immune protection to non-humoral compartments
Type
article
Institution
Externe
Périodique
Auteur(s)
Lang, PO
Auteure/Auteur
Bonduelle, O
Auteure/Auteur
Benhabiles, N
Auteure/Auteur
Combadiere, B
Auteure/Auteur
Liens vers les personnes
ISSN
1878-7649
Statut éditorial
Publié
Date de publication
2014-10
Volume
5
Première page
136
Dernière page/numéro d’article
8
Peer-reviewed
Oui
Langue
anglais
Résumé
Activating different adaptive immune component is required to confer long-time protection against influenza viruses. By investigating the co-mobilization of immune compartments following A/H1N1 2009 pandemic vaccine (A(H1N1)pdm09 influenza vaccine-Panenza(R), Sanofi Pasteur), we show that multiple vaccination with 2000-2003 seasonal influenza vaccines leads to a broader immune repertoire than the one theoretically expected by vaccine strains. Moreover, in case of contact with strains previously encountered, the A(H1N1)pdm09-specific immune response is extended to non-humoral immune components (i.e. CD8+ and/or CD4+ T-cells response).
PID Serval
serval:BIB_68588F5158DB
Date de création
2015-04-15T07:07:37.798Z
Date de création dans IRIS
2025-05-21T04:30:10Z