Titre
Falls, Cognitive Impairment, and Gait Performance: Results From the GOOD Initiative.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Auteur(s)
Allali, G.
Auteure/Auteur
Launay, C.P.
Auteure/Auteur
Blumen, H.M.
Auteure/Auteur
Callisaya, M.L.
Auteure/Auteur
De Cock, A.M.
Auteure/Auteur
Kressig, R.W.
Auteure/Auteur
Srikanth, V.
Auteure/Auteur
Steinmetz, J.P.
Auteure/Auteur
Verghese, J.
Auteure/Auteur
Beauchet, O.
Auteure/Auteur
Groupes de travail
Biomathics Consortium
Liens vers les personnes
Liens vers les unités
ISSN
1538-9375
Statut éditorial
Publié
Date de publication
2017-04-01
Volume
18
Numéro
4
Première page
335
Dernière page/numéro d’article
340
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Multicenter Study
Publication Status: ppublish
Publication Status: ppublish
Résumé
Falls are highly prevalent in individuals with cognitive decline. The complex relationship between falls and cognitive decline (including both subtype and severity of dementia) and the influence of gait disorders have not been studied. This study aimed to examine the association between the subtype (Alzheimer disease [AD] versus non-AD) and the severity (from preclinical to moderate dementia) of cognitive impairment and falls, and to establish an association between falls and gait parameters during the course of dementia.
Multicenter cross-sectional study.
"Gait, cOgnitiOn & Decline" (GOOD) initiative.
A total of 2496 older adults (76.6 ± 7.6 years; 55.0% women) were included in this study (1161 cognitively healthy individuals [CHI], 529 patients with mild cognitive impairment [MCI], 456 patients with mild dementia, and 350 with moderate dementia) from 7 countries.
Falls history was collected retrospectively at baseline in each study. Gait speed and stride time variability were recorded at usual walking pace with the GAITRite system.
The prevalence of individuals who fall was 50% in AD and 64% in non-AD; whereas it was 25% in CHIs. Only mild and moderate non-AD dementia were associated with an increased risk for falls in comparison with CHI. Higher stride time variability was associated with falls in older adults without dementia (CHI and each MCI subgroup) and mild non-AD dementia, whereas lower gait speed was associated with falls in all participant groups, except in mild AD dementia. When gait speed was adjusted for, higher stride time variability was associated with falls only in CHIs (odds ratio 1.14; P = .012), but not in MCI or in patients with dementia.
These findings suggest that non-AD, but not AD dementia, is associated with increased falls in comparison with CHIs. The association between gait parameters and falls also differs across cognitive status, suggesting different mechanisms leading to falls in older individuals with dementia in comparison with CHIs who fall.
Multicenter cross-sectional study.
"Gait, cOgnitiOn & Decline" (GOOD) initiative.
A total of 2496 older adults (76.6 ± 7.6 years; 55.0% women) were included in this study (1161 cognitively healthy individuals [CHI], 529 patients with mild cognitive impairment [MCI], 456 patients with mild dementia, and 350 with moderate dementia) from 7 countries.
Falls history was collected retrospectively at baseline in each study. Gait speed and stride time variability were recorded at usual walking pace with the GAITRite system.
The prevalence of individuals who fall was 50% in AD and 64% in non-AD; whereas it was 25% in CHIs. Only mild and moderate non-AD dementia were associated with an increased risk for falls in comparison with CHI. Higher stride time variability was associated with falls in older adults without dementia (CHI and each MCI subgroup) and mild non-AD dementia, whereas lower gait speed was associated with falls in all participant groups, except in mild AD dementia. When gait speed was adjusted for, higher stride time variability was associated with falls only in CHIs (odds ratio 1.14; P = .012), but not in MCI or in patients with dementia.
These findings suggest that non-AD, but not AD dementia, is associated with increased falls in comparison with CHIs. The association between gait parameters and falls also differs across cognitive status, suggesting different mechanisms leading to falls in older individuals with dementia in comparison with CHIs who fall.
PID Serval
serval:BIB_83D55BF0D97A
PMID
Date de création
2023-10-05T14:59:54.097Z
Date de création dans IRIS
2025-05-20T23:04:48Z