Titre
Boosting mitochondrial health to counteract neurodegeneration.
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Burtscher, J.
Auteure/Auteur
Romani, M.
Auteure/Auteur
Bernardo, G.
Auteure/Auteur
Popa, T.
Auteure/Auteur
Ziviani, E.
Auteure/Auteur
Hummel, F.C.
Auteure/Auteur
Sorrentino, V.
Auteure/Auteur
Millet, G.P.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1873-5118
Statut éditorial
Publié
Date de publication
2022-08
Volume
215
Première page
102289
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
Mitochondrial health is based on a delicate balance of specific mitochondrial functions (e.g. metabolism, signaling, dynamics) that are impaired in neurodegenerative diseases. Rescuing mitochondrial function by selectively targeting mitochondrial stressors, such as reactive oxygen species, inflammation or proteotoxic insults ("bottom-up" approaches) thus is a widely investigated therapeutic strategy. While successful in preclinical studies, these approaches have largely failed to show clear clinical benefits. Promoting the capacity of mitochondria - and other cellular components - to restore a healthy cellular environment is a promising complementary or alternative approach. Herein, we provide a non-technical overview for neurologists and scientists interested in brain metabolism on neuroprotective strategies targeting mitochondria and focus on top-down interventions such as metabolic modulators, exercise, dietary restriction, brain stimulation and conditioning. We highlight general conceptual differences to bottom-up approaches and provide hypotheses on how these mechanistically comparatively poorly characterized top-down therapies may work, discussing notably mitochondrial stress responses and mitohormesis.
PID Serval
serval:BIB_3223F1F38608
PMID
Open Access
Oui
Date de création
2022-05-26T18:24:49.539Z
Date de création dans IRIS
2025-05-20T17:55:33Z
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Nom
ProgNeurobiol-2022-Boosting mitochondrial health.pdf
Version du manuscrit
preprint
Licence
https://creativecommons.org/licenses/by-nc-nd/4.0
Taille
3.07 MB
Format
Adobe PDF
PID Serval
serval:BIB_3223F1F38608.P001
Somme de contrôle
(MD5):b0eb080b5c22b71e1bab97fe4767ffba