Titre
Cellular pathology of mitral valve prolapse.
Type
synthèse (review)
Institution
Externe
Périodique
Auteur(s)
Prunotto, M.
Auteure/Auteur
Caimmi, P.P.
Auteure/Auteur
Bongiovanni, M.
Auteure/Auteur
Liens vers les personnes
ISSN
1879-1336
Statut éditorial
Publié
Date de publication
2010
Volume
19
Numéro
4
Première page
e113
Dernière page/numéro d’article
e117
Langue
anglais
Notes
Publication types: Journal Article ; ReviewPublication Status: ppublish
Résumé
BACKGROUND: Mitral valve prolapse (MVP) is the most frequent cause of chronic, pure, and isolated mitral regurgitation, and is estimated to affect more than 144 million individuals worldwide. This short review focuses in particular on the structural and cellular aspects of MVP in humans. The key microscopic change in MVP appears to occur in the fibrosa, on which the structural integrity of the entire valve depends. Recent discoveries showed that proteoglycans may play an active role in both MVP initiation and/or progression together with valvular interstitial cells. A full understanding of the cellular basis of MVP goes beyond a mere mechanicistic description of the disease, involving the transformation of resting fibroblasts into activated myofibroblasts.
CONCLUSIONS: Mitral valve could represent therefore an ideal environment to study early transformation phases of fibroblasts toward a protomyofibroblast phenotype.
CONCLUSIONS: Mitral valve could represent therefore an ideal environment to study early transformation phases of fibroblasts toward a protomyofibroblast phenotype.
PID Serval
serval:BIB_2D13F35EAB9E
PMID
Date de création
2015-02-05T10:03:45.709Z
Date de création dans IRIS
2025-05-20T15:28:58Z