Titre
Beta-Blocker Use in Pregnancy and Risk of Specific Congenital Anomalies: A European Case-Malformed Control Study.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Auteur(s)
Bergman, JEH
Auteure/Auteur
Lutke, L.R.
Auteure/Auteur
Gans, ROB
Auteure/Auteur
Addor, M.C.
Auteure/Auteur
Barisic, I.
Auteure/Auteur
Cavero-Carbonell, C.
Auteure/Auteur
Garne, E.
Auteure/Auteur
Gatt, M.
Auteure/Auteur
Klungsoyr, K.
Auteure/Auteur
Lelong, N.
Auteure/Auteur
Lynch, C.
Auteure/Auteur
Mokoroa, O.
Auteure/Auteur
Nelen, V.
Auteure/Auteur
Neville, A.J.
Auteure/Auteur
Pierini, A.
Auteure/Auteur
Randrianaivo, H.
Auteure/Auteur
Rissmann, A.
Auteure/Auteur
Tucker, D.
Auteure/Auteur
Wiesel, A.
Auteure/Auteur
Dolk, H.
Auteure/Auteur
Loane, M.
Auteure/Auteur
Bakker, M.K.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1179-1942
Statut éditorial
Publié
Date de publication
2018-04
Volume
41
Numéro
4
Première page
415
Dernière page/numéro d’article
427
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
The prevalence of chronic hypertension is increasing in pregnant women. Beta-blockers are among the most prevalent anti-hypertensive agents used in early pregnancy.
The objective of this study was to investigate whether first-trimester use of beta-blockers increases the risk of specific congenital anomalies in offspring.
A population-based case-malformed control study was conducted in 117,122 registrations of congenital anomalies from 17 European Concerted Action on Congenital Anomalies and Twins (EUROCAT) registries participating in EUROmediCAT with data for all or part of the period between 1995 and 2013. Associations previously reported in the literature (signals) were tested and an exploratory analysis was performed to identify new signals. Odds ratios of exposure to any beta-blocker or to a beta-blocker subgroup were calculated for each signal anomaly compared with two control groups (non-chromosomal, non-signal anomalies and chromosomal anomalies). The exploratory analyses were performed for each non-signal anomaly compared with all the other non-signal anomalies.
The signals from the literature (congenital heart defects, oral clefts, neural tube defects and hypospadias) were not confirmed. Our exploratory analysis revealed that multi-cystic renal dysplasia had significantly increased odds of occurring after maternal exposure to combined alpha- and beta-blockers (adjusted odds ratio 3.8; 95% confidence interval 1.3-11.0).
Beta-blocker use in the first trimester of pregnancy was not found to be associated with a higher risk of specific congenital anomalies in the offspring, but a new signal between alpha- and beta-blockers and multi-cystic renal dysplasia was found. Future large epidemiological studies are needed to confirm or refute our findings.
The objective of this study was to investigate whether first-trimester use of beta-blockers increases the risk of specific congenital anomalies in offspring.
A population-based case-malformed control study was conducted in 117,122 registrations of congenital anomalies from 17 European Concerted Action on Congenital Anomalies and Twins (EUROCAT) registries participating in EUROmediCAT with data for all or part of the period between 1995 and 2013. Associations previously reported in the literature (signals) were tested and an exploratory analysis was performed to identify new signals. Odds ratios of exposure to any beta-blocker or to a beta-blocker subgroup were calculated for each signal anomaly compared with two control groups (non-chromosomal, non-signal anomalies and chromosomal anomalies). The exploratory analyses were performed for each non-signal anomaly compared with all the other non-signal anomalies.
The signals from the literature (congenital heart defects, oral clefts, neural tube defects and hypospadias) were not confirmed. Our exploratory analysis revealed that multi-cystic renal dysplasia had significantly increased odds of occurring after maternal exposure to combined alpha- and beta-blockers (adjusted odds ratio 3.8; 95% confidence interval 1.3-11.0).
Beta-blocker use in the first trimester of pregnancy was not found to be associated with a higher risk of specific congenital anomalies in the offspring, but a new signal between alpha- and beta-blockers and multi-cystic renal dysplasia was found. Future large epidemiological studies are needed to confirm or refute our findings.
PID Serval
serval:BIB_8367D2490EED
PMID
Open Access
Oui
Date de création
2018-01-30T08:29:54.474Z
Date de création dans IRIS
2025-05-20T23:39:03Z
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Nom
29230691METTRE EN WEB.pdf
Version du manuscrit
published
Taille
569.41 KB
Format
Adobe PDF
PID Serval
serval:BIB_8367D2490EED.P001
URN
urn:nbn:ch:serval-BIB_8367D2490EED1
Somme de contrôle
(MD5):cfdb8473ee8a8c49c3838541eae796b4