Titre
The venous tone is not altered after three-week tail suspension in rats.
Type
article
Institution
Externe
Périodique
Journal of Gravitational Physiology
Auteur(s)
Louisy, F.
Auteure/Auteur
Tran, C.C.
Auteure/Auteur
Resch, G.
Auteure/Auteur
Luce, P.
Auteure/Auteur
Lemarquer, F.
Auteure/Auteur
Finet, M.
Auteure/Auteur
Liens vers les personnes
ISSN
1077-9248
Statut éditorial
Publié
Date de publication
1998
Volume
5
Numéro
1
Première page
P47
Dernière page/numéro d’article
8
Peer-reviewed
Oui
Langue
anglais
Résumé
Cardiovascular deconditioning observed in humans during spaceflight has been suggested to be related in part to changes in venous compliance, mechanisms including skeletal muscle deconditioning. However, increased venous compliance was observed during very short term simulations (24 to 48 hours), and during an over 28-day simulation the hyperdistensibility tended to decrease whereas the muscular changes were still present (2). In the first case, muscular changes can not explain the venous alterations because of the short delay. In the second case, the relationship between muscular and venous alterations disappeared. Finally, it is suggested that factors other than muscular ones could explain the changes in venous compliance observed during spaceflights. The fact that orthostatic hypotension has never been observed after hindlimb suspension in the rat raises issue with the use of tail-suspended rats as a valid model for the study of the mechanisms involved in cardiovascular deconditioning induced by spaceflight in humans. However, in vitro altered responsiveness of the vena cava to norepinephrine were observed in rat after spaceflight and tail suspension. The purpose of the experiments was to verify if any change occurs in venous tone measured in vivo in rats after three-week tail suspension.
PID Serval
serval:BIB_2D59AB480D99
PMID
Date de création
2017-02-17T08:01:53.733Z
Date de création dans IRIS
2025-05-20T19:18:04Z