Titre
Prognostic value of dipyridamole stress cardiac magnetic resonance in patients with known or suspected coronary artery disease: a mid-term follow-up study.
Type
article
Institution
Externe
Périodique
Auteur(s)
Pontone, G.
Auteure/Auteur
Andreini, D.
Auteure/Auteur
Bertella, E.
Auteure/Auteur
Loguercio, M.
Auteure/Auteur
Guglielmo, M.
Auteure/Auteur
Baggiano, A.
Auteure/Auteur
Aquaro, G.D.
Auteure/Auteur
Mushtaq, S.
Auteure/Auteur
Salerni, S.
Auteure/Auteur
Gripari, P.
Auteure/Auteur
Rossi, C.
Auteure/Auteur
Segurini, C.
Auteure/Auteur
Conte, E.
Auteure/Auteur
Beltrama, V.
Auteure/Auteur
Giovannardi, M.
Auteure/Auteur
Veglia, F.
Auteure/Auteur
Guaricci, A.I.
Auteure/Auteur
Bartorelli, A.L.
Auteure/Auteur
Agostoni, P.
Auteure/Auteur
Pepi, M.
Auteure/Auteur
Masci, P.G.
Auteure/Auteur
Liens vers les personnes
ISSN
1432-1084
Statut éditorial
Publié
Date de publication
2016-07
Volume
26
Numéro
7
Première page
2155
Dernière page/numéro d’article
2165
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
Dipyridamole stress cardiac magnetic resonance (CMR) evaluates the key phases (perfusion and wall motion) of the ischemic cascade. We sought to determine the prognostic value of dipyridamole stress-CMR in consecutive patients symptomatic for chest pain.
Seven hundred and ninety-three consecutive patients symptomatic for chest pain underwent dipyridamole stress-CMR and were followed up for 810 ± 665 days. Patients were classified in group 1 (no- reversible ischemia), group 2 (stress perfusion defect alone), and group 3 [stress perfusion defect plus abnormal wall motion (AWM)]. End points were "all cardiac events" (myocardial infarction, cardiac death and revascularization) and "hard cardiac events" (all cardiac events excluding revascularization).
One hundred and ninety-five (24 %) all cardiac events and 53 (7 %) hard cardiac events were observed. All and hard cardiac event rates in groups 1, 2, and 3 were 11 %, 49 %, 69 % and 4 %, 8 %, 21 %, respectively, with a higher rate in group 2 vs. group 1 (p<0.01) and group 3 vs. groups 1 and 2 (p<0.01). Multivariate analysis showed the presence of late gadolinium enhancement and stress perfusion defect plus AWM as independent predictors of all and hard cardiac events.
Dipyridamole stress-CMR improves prognostic stratification of patients through differentiation between the different components of the ischemic cascade.
• Dipyridamole stress cardiac magnetic resonance helps to assess coronary artery disease. • Novel technique to study the key phases of myocardial ischemia. • Combined assessment of perfusion and motion defects. • Dipyridamole stress imaging has additional value for predicting cardiac events.
Seven hundred and ninety-three consecutive patients symptomatic for chest pain underwent dipyridamole stress-CMR and were followed up for 810 ± 665 days. Patients were classified in group 1 (no- reversible ischemia), group 2 (stress perfusion defect alone), and group 3 [stress perfusion defect plus abnormal wall motion (AWM)]. End points were "all cardiac events" (myocardial infarction, cardiac death and revascularization) and "hard cardiac events" (all cardiac events excluding revascularization).
One hundred and ninety-five (24 %) all cardiac events and 53 (7 %) hard cardiac events were observed. All and hard cardiac event rates in groups 1, 2, and 3 were 11 %, 49 %, 69 % and 4 %, 8 %, 21 %, respectively, with a higher rate in group 2 vs. group 1 (p<0.01) and group 3 vs. groups 1 and 2 (p<0.01). Multivariate analysis showed the presence of late gadolinium enhancement and stress perfusion defect plus AWM as independent predictors of all and hard cardiac events.
Dipyridamole stress-CMR improves prognostic stratification of patients through differentiation between the different components of the ischemic cascade.
• Dipyridamole stress cardiac magnetic resonance helps to assess coronary artery disease. • Novel technique to study the key phases of myocardial ischemia. • Combined assessment of perfusion and motion defects. • Dipyridamole stress imaging has additional value for predicting cardiac events.
Sujets
PID Serval
serval:BIB_303E5AC05D0A
PMID
Date de création
2017-08-25T19:15:56.572Z
Date de création dans IRIS
2025-05-20T14:55:13Z