Titre
Cushing's syndrome due to a pancreatic neuroendocrine tumor metastatic to the ovaries: a clinicopathological description of a case.
Type
étude de cas
Institution
Externe
Périodique
Auteur(s)
La Rosa, S.
Auteure/Auteur
Marando, A.
Auteure/Auteur
Ghezzi, F.
Auteure/Auteur
Colombo, P.
Auteure/Auteur
Finzi, G.
Auteure/Auteur
Capella, C.
Auteure/Auteur
Liens vers les personnes
ISSN
1559-0097
Statut éditorial
Publié
Date de publication
2011
Volume
22
Numéro
2
Première page
118
Dernière page/numéro d’article
124
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Case Reports ; Journal ArticlePublication Status: ppublish
Résumé
We report the case of a 36-year-old woman with Cushing's syndrome caused by a malignant unresectable neuroendocrine carcinoma of the pancreas that developed bilateral ovarian metastases 7 years after diagnosis. In November 2001, because of abdominal pain and jaundice, the patient underwent radiological investigations and exploratory laparotomy that demonstrated the presence of a 3-cm mass of the head of the pancreas, infiltrating the superior mesenteric vein, associated with enlargement of multiple abdominal lymph nodes and with a liver nodule. Histological examination of one lymph node and of the liver nodule demonstrated the presence of metastases from a well-differentiated neuroendocrine carcinoma showing corticotropin immunoreactivity. A few months later, the patient started to show the clinical symptoms of Cushing's syndrome and underwent steroid-blocking ketoconazole therapy. The clinical endocrine picture was controlled until the end of 2008, when the endocrine symptoms of the Cushing's syndrome worsened and bilateral ovarian tumors appeared. Hysteroannexectomy was performed and ovarian tumors were found to be metastases from a well-differentiated neuroendocrine carcinoma with morphological and immunohistochemical features overlapping those observed in 2002. The clinical situation worsened and the patient died in November 2009. The clinical aspects and the problems in the differential diagnosis are discussed.
Sujets
PID Serval
serval:BIB_85DBC42E86C2
PMID
Date de création
2016-09-06T12:24:33.885Z
Date de création dans IRIS
2025-05-21T00:35:51Z