Titre
Prevalence of Incidental Findings Suspicious for Transthyretin Cardiac Amyloidosis among Patients Undergoing Bone Scintigraphy: A Systematic Review and a Meta-Analysis.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Treglia, G.
Auteure/Auteur
Martinello, C.
Auteure/Auteur
Dondi, F.
Auteure/Auteur
Albano, D.
Auteure/Auteur
Bertagna, F.
Auteure/Auteur
Rizzo, A.
Auteure/Auteur
Delgado Bolton, R.C.
Auteure/Auteur
Tersalvi, G.
Auteure/Auteur
Muoio, B.
Auteure/Auteur
Riegger, M.
Auteure/Auteur
Cecchin, D.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
2077-0383
Statut éditorial
Publié
Date de publication
2023-09-01
Volume
12
Numéro
17
Première page
5698
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Publication Status: epublish
Résumé
The myocardial uptake of bone-seeking tracers suspicious for transthyretin cardiac amyloidosis (ATTR-CA) can be incidentally detected in patients undergoing bone scintigraphy for noncardiac reasons. We conducted a systematic review and meta-analysis to assess the prevalence of these scintigraphic findings.
A comprehensive literature search was performed using two bibliographic databases (PubMed/MEDLINE and Cochrane Library), searching for articles related to the review question. Eligible articles were selected, and relevant data were extracted by two authors. The pooled prevalence of incidental findings suspicious for ATTR-CA among patients undergoing bone scintigraphy was calculated on a per-patient-based analysis using a random-effects model. The pooled measure was provided with 95% confidence interval (95% CI) values.
Among 219 records, 11 articles were selected for the systematic review and 10 for the meta-analysis. The pooled prevalence of incidental findings suspicious for ATTR-CA was 1.1% (95% CI: 0.7-1.4%) with heterogeneity due to the characteristics of the included studies, patients, and index tests. These findings are more prevalent in older men.
The prevalence of incidental findings of ATTR-CA among patients undergoing bone scintigraphy is low but not negligible. Nuclear medicine physicians should suggest, in the scintigraphic report, further clinical investigations when these findings are detected. Prospective studies are warranted.
A comprehensive literature search was performed using two bibliographic databases (PubMed/MEDLINE and Cochrane Library), searching for articles related to the review question. Eligible articles were selected, and relevant data were extracted by two authors. The pooled prevalence of incidental findings suspicious for ATTR-CA among patients undergoing bone scintigraphy was calculated on a per-patient-based analysis using a random-effects model. The pooled measure was provided with 95% confidence interval (95% CI) values.
Among 219 records, 11 articles were selected for the systematic review and 10 for the meta-analysis. The pooled prevalence of incidental findings suspicious for ATTR-CA was 1.1% (95% CI: 0.7-1.4%) with heterogeneity due to the characteristics of the included studies, patients, and index tests. These findings are more prevalent in older men.
The prevalence of incidental findings of ATTR-CA among patients undergoing bone scintigraphy is low but not negligible. Nuclear medicine physicians should suggest, in the scintigraphic report, further clinical investigations when these findings are detected. Prospective studies are warranted.
PID Serval
serval:BIB_FF150429E2ED
PMID
Open Access
Oui
Date de création
2023-09-25T14:20:58.906Z
Date de création dans IRIS
2025-05-21T07:11:01Z
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Nom
37685765_BIB_FF150429E2ED.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by/4.0
Taille
1.36 MB
Format
Adobe PDF
PID Serval
serval:BIB_FF150429E2ED.P001
URN
urn:nbn:ch:serval-BIB_FF150429E2ED5
Somme de contrôle
(MD5):cbb4a56a2a1fc09d7d3df551ac1be2b2