Titre
Cis-trans interactions of cell surface receptors: biological roles and structural basis.
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Held, W.
Auteure/Auteur
Mariuzza, R.A.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1420-9071
Statut éditorial
Publié
Date de publication
2011
Volume
68
Numéro
21
Première page
3469
Dernière page/numéro d’article
3478
Langue
anglais
Résumé
Cell surface receptors bind ligands expressed on other cells (in trans) in order to communicate with neighboring cells. However, an increasing number of cell surface receptors are found to also interact with ligands expressed on the same cell (in cis). These observations raise questions regarding the biological role of such cis interactions. Specifically, it is important to know whether cis and trans binding have distinct functional effects and, if so, how a single cell discriminates between interactions in cis versus trans. Further, what are the structural features that allow certain cell surface receptors to engage ligand both on the same as well as on an apposed cell membrane? Here, we summarize known examples of receptors that display cis-trans binding and discuss the emerging diversity of biological roles played by these unconventional two-way interactions, along with their structural basis.
PID Serval
serval:BIB_7D095BF6B21B
PMID
Open Access
Oui
Date de création
2012-02-16T14:07:02.061Z
Date de création dans IRIS
2025-05-21T01:06:46Z
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Nom
REF.pdf
Version du manuscrit
published
Taille
1.76 MB
Format
Adobe PDF
PID Serval
serval:BIB_7D095BF6B21B.P001
URN
urn:nbn:ch:serval-BIB_7D095BF6B21B5
Somme de contrôle
(MD5):4384664e216d7543dc8b409988708989