Titre
Spine changes associated with long-term potentiation.
Type
synthèse (review)
Institution
Externe
Périodique
Auteur(s)
Muller, D.
Auteure/Auteur
Toni, N.
Auteure/Auteur
Buchs, P.A.
Auteure/Auteur
Liens vers les personnes
ISSN
1050-9631
Statut éditorial
Publié
Date de publication
2000
Volume
10
Numéro
5
Première page
596
Dernière page/numéro d’article
604
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review Publication Status: ppublish
Résumé
High-frequency stimulation of excitatory synapses in many regions of the brain triggers a lasting increase in the efficacy of synaptic transmission referred to as long-term potentiation (LTP) and believed to contribute to learning and memory. One hypothesis proposed to account for the stability and properties of this functional plasticity is a structural remodeling of spine synapses. This possibility has recently received support from several studies. It has been found that spines are highly dynamic structures, that they can be formed very rapidly, and that synaptic activity and calcium modulate changes in spine shape and formation of new spines. Ultrastructural analyses bring additional support to these observations and suggest that LTP is associated with a remodeling of the postsynaptic density (PSD) and a process of spine duplication. This new information is reviewed and interpreted in light of other recent advances concerning the mechanisms of LTP and especially the role of postsynaptic glutamate receptor turnover in this form of plasticity. Taken together, a view is emerging that suggests that morphologic changes of spine synapses are associated with LTP and that they not only correlate with, but probably also contribute to the increase in synaptic transmission.
PID Serval
serval:BIB_896E962B1F5A
PMID
Date de création
2010-01-22T07:00:25.454Z
Date de création dans IRIS
2025-05-20T23:37:51Z