Titre
Brain-derived neurotrophic factor plasma variation during the different phases of the menstrual cycle in women with premenstrual syndrome.
Type
article
Institution
Externe
Périodique
Auteur(s)
Cubeddu, A.
Auteure/Auteur
Bucci, F.
Auteure/Auteur
Giannini, A.
Auteure/Auteur
Russo, M.
Auteure/Auteur
Daino, D.
Auteure/Auteur
Russo, N.
Auteure/Auteur
Merlini, S.
Auteure/Auteur
Pluchino, N.
Auteure/Auteur
Valentino, V.
Auteure/Auteur
Casarosa, E.
Auteure/Auteur
Luisi, S.
Auteure/Auteur
Genazzani, A.R.
Auteure/Auteur
Liens vers les personnes
ISSN
1873-3360
Statut éditorial
Publié
Date de publication
2011-05
Volume
36
Numéro
4
Première page
523
Dernière page/numéro d’article
530
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
Premenstrual syndrome (PMS) is characterized by a cluster of psychological and somatic symptoms that begin during the late luteal phase of the menstrual cycle and disappear after the onset of menses. Since PMS might be caused by an alteration in the cyclical hormonal modifications and ovarian steroids are directly involved in the regulation of mood, affective and cognitive functions and influence neurotrophins expression, in particular the brain-derived neurotrophic factor (BDNF), we aimed to evaluate whether plasma BDNF levels in women with PMS differ from those of normally menstruating women without PMS. Sixty-two women were divided into two groups: one group of women (n=35) with PMS and one group (n=27) composed by normally menstruating women. Plasma samples were collected at day 7 (follicular phase) and day 21 (luteal phase) of the menstrual cycle. Plasma BDNF of the control group significantly increased (p<0.001) from the follicular phase (402.90±74.41pg/ml) to the luteal phase (1098.79±146.49pg/ml). On the other hand, in the PMS group plasma BDNF levels significantly decreased (p<0.001) from the follicular phase (412.45±78.35pg/ml) to the luteal phase (233.03±75.46pg/ml) Luteal BDNF levels of the PMS women were significantly lower than those of the control group (p<0.001). In women with PMS, plasma BDNF followed a decreasing trend during the ovarian cycle, in opposition to the increasing trend observed in women without PMS. The lower luteal BDNF levels of the PMS women might be a consequence of an altered hormonal response and might play a role in the onset of the symptoms PMS related.
Sujets
PID Serval
serval:BIB_DFD832237CE4
PMID
Date de création
2023-09-15T11:24:48.791Z
Date de création dans IRIS
2025-05-21T05:08:53Z