Titre
Risk stratification and immunogenetic risk for infections following stem cell transplantation.
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Wójtowicz, A.
Auteure/Auteur
Bochud, P.Y.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
2150-5608
Statut éditorial
Publié
Date de publication
2016-11-16
Volume
7
Numéro
8
Première page
917
Dernière page/numéro d’article
929
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Résumé
Patients undergoing haematopoietic stem cell transplantation (HSCT) are highly exposed to infectious agents. However, it is not known why certain HSCT recipients rapidly develop severe infections while other, despite similar immunosuppressive conditions, do not. Increasing evidence suggests that such differences may be due, in part, to polymorphisms in immune genes. Thus, the identification of genetic factors influencing susceptibility to infections in HSCT recipients may lead to the development of individualized management strategies. However, studies are challenged by several issues, including the relative small size of existing cohorts, the frequent use of prophylactic or preemptive antimicrobial agents, and the fact that genes responsible for immune functions can be inherited either from the donor or the host. Consequently, the major challenge for today's researchers is to overcome these limitations and find associations that are robust enough to be translated into reliable risk stratification strategies for infectious diseases.
Sujets
PID Serval
serval:BIB_846A63D54C53
PMID
Open Access
Oui
Date de création
2017-01-13T10:43:50.565Z
Date de création dans IRIS
2025-05-20T22:34:52Z