Titre
Stereologic estimates of total spinophilin-immunoreactive spine number in area 9 and the CA1 field: relationship with the progression of Alzheimer's disease.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Akram, A.
Auteure/Auteur
Christoffel, D.
Auteure/Auteur
Rocher, A.B.
Auteure/Auteur
Bouras, C.
Auteure/Auteur
Kövari, E.
Auteure/Auteur
Perl, D.P.
Auteure/Auteur
Morrison, J.H.
Auteure/Auteur
Herrmann, F.R.
Auteure/Auteur
Haroutunian, V.
Auteure/Auteur
Giannakopoulos, P.
Auteure/Auteur
Hof, P.R.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1558-1497[electronic]
Statut éditorial
Publié
Date de publication
2009
Volume
29
Numéro
9
Première page
1296
Dernière page/numéro d’article
307
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Résumé
The loss of presynaptic markers is thought to represent a strong pathologic correlate of cognitive decline in Alzheimer's disease (AD). Spinophilin is a postsynaptic marker mainly located to the heads of dendritic spines. We assessed total numbers of spinophilin-immunoreactive puncta in the CA1 and CA3 fields of hippocampus and area 9 in 18 elderly individuals with various degrees of cognitive decline. The decrease in spinophilin-immunoreactivity was significantly related to both Braak neurofibrillary tangle (NFT) staging and clinical severity but not A beta deposition staging. The total number of spinophilin-immunoreactive puncta in CA1 field and area 9 were significantly related to MMSE scores and predicted 23.5 and 61.9% of its variability. The relationship between total number of spinophilin-immunoreactive puncta in CA1 field and MMSE scores did not persist when adjusting for Braak NFT staging. In contrast, the total number of spinophilin-immunoreactive puncta in area 9 was still significantly related to the cognitive outcome explaining an extra 9.6% of MMSE and 25.6% of the Clinical Dementia Rating scores variability. Our data suggest that neocortical dendritic spine loss is an independent parameter to consider in AD clinicopathologic correlations.
PID Serval
serval:BIB_B8E813B577CA
PMID
Date de création
2008-03-10T10:04:11.507Z
Date de création dans IRIS
2025-05-20T21:49:31Z