Titre
Hypovitaminosis D and response to cholecalciferol supplementation in patients with autoimmune and non-autoimmune rheumatic diseases.
Type
article
Institution
Externe
Périodique
Auteur(s)
Sainaghi, P.P.
Auteure/Auteur
Bellan, M.
Auteure/Auteur
Carda, S.
Auteure/Auteur
Cerutti, C.
Auteure/Auteur
Sola, D.
Auteure/Auteur
Nerviani, A.
Auteure/Auteur
Molinari, R.
Auteure/Auteur
Cisari, C.
Auteure/Auteur
Avanzi, G.C.
Auteure/Auteur
Liens vers les personnes
ISSN
1437-160X
Statut éditorial
Publié
Date de publication
2012
Volume
32
Numéro
11
Première page
3365
Dernière page/numéro d’article
3372
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
Recent reports suggest a role of hypovitaminosis D in the pathogenesis of inflammatory autoimmune diseases (ARD); we investigated 25(OH)vitamin D plasma level before and after supplementation in ARD and NARD (non-ARD: osteoporosis and/or OA) patients. We retrospectively evaluated 572 consecutive clinical records of adult patients at immuno-rheumatology and rehabilitative units of our institution from January 2006 to October 2009. We excluded patients with vitamin D supplementation or renal failure, primary hyperparathyroidism, liver failure. We recorded 25(OH)vitamin D plasma concentration of 245 patients together with other clinical data. We then evaluated 25(OH)vitamin D plasma concentration of 100 (43 ARD and 57 NARD) patients previously included who underwent 750-1,000 UI/die 25(OH)vitamin D supplementation for at least 6 months. Appropriate statistical analysis was performed. The median 25(OH)vitamin D concentration was not significantly different between 119 ARD [33.4 (IQR 22.5-54.9) nmol/l] and 126 NARD patients 32.9 (IQR 18.7-50.2). In stepwise logistic regression, female sex (F:13.7), winter-spring season (F:5.6) and older age (F:5.3), but not ARD, predicted plasma 25(OH)vitamin D <75 nmol/l. Cholecalciferol supplementation increased 25(OH)vitamin D plasma concentration equally in both ARD and NARD; however, only 29/100 patients reached a plasma level ≥75 nmol/l without differences between ARD and NARD (χ(2) = n.s.). Hypovitaminosis D is common in rheumatic patients. Sex and age but not ARD are risk factors for this condition. 750-1,000 UI/die of cholecalciferol is not sufficient to normalize plasma level in these patients. Increase of plasma 25(OH)vitamin D after treatment is not influenced by the presence of an inflammatory autoimmune disease.
Sujets
PID Serval
serval:BIB_378E87BAE7A7
PMID
Date de création
2013-03-25T16:14:52.162Z
Date de création dans IRIS
2025-05-20T17:59:36Z
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Sainaghi2012_Article_HypovitaminosisDAndResponseToC.pdf
Version du manuscrit
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Taille
388.26 KB
Format
Adobe PDF
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