Titre
Plasmacytoid dendritic cells in the skin: to sense or not to sense nucleic acids.
Type
synthèse (review)
Institution
Externe
Périodique
Auteur(s)
Conrad, C.
Auteure/Auteur
Meller, S.
Auteure/Auteur
Gilliet, M.
Auteure/Auteur
Liens vers les personnes
ISSN
1096-3618
Statut éditorial
Publié
Date de publication
2009
Volume
21
Numéro
3
Première page
101
Dernière page/numéro d’article
109
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Résumé
Plasmacytoid dendritic cells (pDCs) are specialized sensors of viral nucleic acids that initiate protective immunity through the production of type I interferons (IFNs). Normally, pDCs fail to sense host-derived self-nucleic acids but do so when self-nucleic acids form complexes with endogenous antimicrobial peptides produced in damaged skin. Whereas regulated expression of antimicrobial peptides may lead to pDC activation and protective immune responses to skin injury, overexpression of antimicrobial peptides in psoriasis drives excessive sensing of self-nucleic acids by pDCs resulting in IFN-driven autoimmunity. In skin tumors, pDCs are unable to sense self-nucleic acids; however, therapeutic activation of pDCs by synthetic nucleic acids or analogues can be exploited to generate antitumor immunity.
Sujets
PID Serval
serval:BIB_5488BF5638A3
PMID
Date de création
2012-03-26T09:28:10.770Z
Date de création dans IRIS
2025-05-20T20:50:56Z