Titre
Induction of a cytotoxic T lymphocyte response by immunization with a malaria specific CTL peptide entrapped in biodegradable polymer microspheres
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Men, Y.
Auteure/Auteur
Tamber, H.
Auteure/Auteur
Audran, R.
Auteure/Auteur
Gander, B.
Auteure/Auteur
Corradin, G.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0264-410X
Statut éditorial
Publié
Date de publication
1997-09
Volume
15
Numéro
12-13
Première page
1405
Dernière page/numéro d’article
12
Peer-reviewed
Oui
Langue
anglais
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Aug-Sep
Research Support, Non-U.S. Gov't --- Old month value: Aug-Sep
Résumé
We have previously reported that biodegradable polymer microspheres (MS) are capable of eliciting strong and long-lasting antibody and T cell proliferative responses for either natural protein antigens or synthetic peptides. In this study, we investigated the possibility of inducing antigen-specific cytotoxic T lymphocyte (CTL) responses in vivo with a short synthetic peptide from the circumsporozoite (CS) protein of Plasmodium berghei (Pb) 252-260 by using different MS formulations. We show that injection of mice with a short CTL epitope microencapsulated in MS or adsorbed on empty MS enhanced a specific CTL response comparable to that obtained with the incomplete Freund's adjuvant (IFA) formulation, indicating that MS are a potent antigen delivery system/immunostimulant for CTL response. These results might be of practical interest for MS preparation and development of subunit vaccines.
Sujets
PID Serval
serval:BIB_47DF33DCE046
PMID
Date de création
2008-01-24T13:55:12.579Z
Date de création dans IRIS
2025-05-20T19:26:43Z