Titre
Very high-energy electron therapy as light-particle alternative to transmission proton FLASH therapy - An evaluation of dosimetric performances.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Böhlen, T.T.
Auteure/Auteur
Germond, J.F.
Auteure/Auteur
Desorgher, L.
Auteure/Auteur
Veres, I.
Auteure/Auteur
Bratel, A.
Auteure/Auteur
Landström, E.
Auteure/Auteur
Engwall, E.
Auteure/Auteur
Herrera, F.G.
Auteure/Auteur
Ozsahin, E.M.
Auteure/Auteur
Bourhis, J.
Auteure/Auteur
Bochud, F.
Auteure/Auteur
Moeckli, R.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1879-0887
Statut éditorial
Publié
Date de publication
2024-05
Volume
194
Première page
110177
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
Clinical translation of FLASH-radiotherapy (RT) to deep-seated tumours is still a technological challenge. One proposed solution consists of using ultra-high dose rate transmission proton (TP) beams of about 200-250 MeV to irradiate the tumour with the flat entrance of the proton depth-dose profile. This work evaluates the dosimetric performance of very high-energy electron (VHEE)-based RT (50-250 MeV) as a potential alternative to TP-based RT for the clinical transfer of the FLASH effect.
Basic physics characteristics of VHEE and TP beams were compared utilizing Monte Carlo simulations in water. A VHEE-enabled research treatment planning system was used to evaluate the plan quality achievable with VHEE beams of different energies, compared to 250 MeV TP beams for a glioblastoma, an oesophagus, and a prostate cancer case.
Like TP, VHEE above 100 MeV can treat targets with roughly flat (within ± 20 %) depth-dose distributions. The achievable dosimetric target conformity and adjacent organs-at-risk (OAR) sparing is consequently driven for both modalities by their lateral beam penumbrae. Electron beams of 400[500] MeV match the penumbra of 200[250] MeV TP beams and penumbra is increased for lower electron energies. For the investigated patient cases, VHEE plans with energies of 150 MeV and above achieved a dosimetric plan quality comparable to that of 250 MeV TP plans. For the glioblastoma and the oesophagus case, although having a decreased conformity, even 100 MeV VHEE plans provided a similar target coverage and OAR sparing compared to TP.
VHEE-based FLASH-RT using sufficiently high beam energies may provide a lighter-particle alternative to TP-based FLASH-RT with comparable dosimetric plan quality.
Basic physics characteristics of VHEE and TP beams were compared utilizing Monte Carlo simulations in water. A VHEE-enabled research treatment planning system was used to evaluate the plan quality achievable with VHEE beams of different energies, compared to 250 MeV TP beams for a glioblastoma, an oesophagus, and a prostate cancer case.
Like TP, VHEE above 100 MeV can treat targets with roughly flat (within ± 20 %) depth-dose distributions. The achievable dosimetric target conformity and adjacent organs-at-risk (OAR) sparing is consequently driven for both modalities by their lateral beam penumbrae. Electron beams of 400[500] MeV match the penumbra of 200[250] MeV TP beams and penumbra is increased for lower electron energies. For the investigated patient cases, VHEE plans with energies of 150 MeV and above achieved a dosimetric plan quality comparable to that of 250 MeV TP plans. For the glioblastoma and the oesophagus case, although having a decreased conformity, even 100 MeV VHEE plans provided a similar target coverage and OAR sparing compared to TP.
VHEE-based FLASH-RT using sufficiently high beam energies may provide a lighter-particle alternative to TP-based FLASH-RT with comparable dosimetric plan quality.
Sujets
PID Serval
serval:BIB_825ACAC4F6E5
PMID
Open Access
Oui
Date de création
2024-02-26T10:47:50.017Z
Date de création dans IRIS
2025-05-20T23:37:44Z
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Nom
38378075.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by/4.0
Taille
6.38 MB
Format
Adobe PDF
PID Serval
serval:BIB_825ACAC4F6E5.P001
URN
urn:nbn:ch:serval-BIB_825ACAC4F6E51
Somme de contrôle
(MD5):d16d6634f4d436f70bf4dd84878a06ed