Titre
Central serous chorioretinopathy: Recent findings and new physiopathology hypothesis.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Daruich, A.
Auteure/Auteur
Matet, A.
Auteure/Auteur
Dirani, A.
Auteure/Auteur
Bousquet, E.
Auteure/Auteur
Zhao, M.
Auteure/Auteur
Farman, N.
Auteure/Auteur
Jaisser, F.
Auteure/Auteur
Behar-Cohen, F.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1873-1635
Statut éditorial
Publié
Date de publication
2015
Volume
48
Première page
82
Dernière page/numéro d’article
118
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Publication Status: ppublish
Résumé
Central serous chorioretinopathy (CSCR) is a major cause of vision threat among middle-aged male individuals. Multimodal imaging led to the description of a wide range of CSCR manifestations, and highlighted the contribution of the choroid and pigment epithelium in CSCR pathogenesis. However, the exact molecular mechanisms of CSCR have remained uncertain. The aim of this review is to recapitulate the clinical understanding of CSCR, with an emphasis on the most recent findings on epidemiology, risk factors, clinical and imaging diagnosis, and treatments options. It also gives an overview of the novel mineralocorticoid pathway hypothesis, from animal data to clinical evidences of the biological efficacy of oral mineralocorticoid antagonists in acute and chronic CSCR patients. In rodents, activation of the mineralocorticoid pathway in ocular cells either by intravitreous injection of its specific ligand, aldosterone, or by over-expression of the receptor specifically in the vascular endothelium, induced ocular phenotypes carrying many features of acute CSCR. Molecular mechanisms include expression of the calcium-dependent potassium channel (KCa2.3) in the endothelium of choroidal vessels, inducing subsequent vasodilation. Inappropriate or over-activation of the mineralocorticoid receptor in ocular cells and other tissues (such as brain, vessels) could link CSCR with the known co-morbidities observed in CSCR patients, including hypertension, coronary disease and psychological stress.
PID Serval
serval:BIB_3A01220E0FF1
PMID
Open Access
Oui
Date de création
2015-08-17T08:43:21.289Z
Date de création dans IRIS
2025-05-20T17:55:34Z
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Nom
BIB_3A01220E0FF1.P001.pdf
Version du manuscrit
published
Taille
9.03 MB
Format
Adobe PDF
PID Serval
serval:BIB_3A01220E0FF1.P001
URN
urn:nbn:ch:serval-BIB_3A01220E0FF12
Somme de contrôle
(MD5):d275cdb92af6f813c36a299c3e4a4a5c