Titre
Cardiovascular response to prescribed detraining among recreational athletes.
Type
article
Institution
Externe
Périodique
Auteur(s)
Pedlar, C.R.
Auteure/Auteur
Brown, M.G.
Auteure/Auteur
Shave, R.E.
Auteure/Auteur
Otto, J.M.
Auteure/Auteur
Drane, A.
Auteure/Auteur
Michaud-Finch, J.
Auteure/Auteur
Contursi, M.
Auteure/Auteur
Wasfy, M.M.
Auteure/Auteur
Hutter, A.
Auteure/Auteur
Picard, M.H.
Auteure/Auteur
Lewis, G.D.
Auteure/Auteur
Baggish, A.L.
Auteure/Auteur
Liens vers les personnes
ISSN
1522-1601
Statut éditorial
Publié
Date de publication
2018-04-01
Volume
124
Numéro
4
Première page
813
Dernière page/numéro d’article
820
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
Exercise-induced cardiac remodeling (EICR) and the attendant myocardial adaptations characteristic of the athlete's heart may regress during periods of exercise reduction or abstinence. The time course and mechanisms underlying this reverse remodeling, specifically the impact of concomitant plasma volume (PV) contraction on cardiac chamber size, remain incompletely understood. We therefore studied recreational runners ( n = 21, age 34 ± 7 yr; 48% male) who completed an 18-wk training program (~7 h/wk) culminating in the 2016 Boston Marathon after which total exercise exposure was confined to <2 h/wk (no single session >1 h) for 8 wk. Cardiac structure and function, exercise capacity, and PV were assessed at peak fitness (10-14 days before) and at 4 wk and 8 wk postmarathon. Mixed linear modeling adjusting for age, sex, V̇o <sub>2peak</sub> , and marathon finish time was used to compare data across time points. Physiological detraining was evidenced by serial reductions in treadmill performance. Two distinct phases of myocardial remodeling and hematological adaptation were observed. After 4 wk of detraining, there were significant reductions in PV (Δ -6.0%, P < 0.01), left ventricular (LV) wall thickness (Δ -8.1%, <0.05), LV mass (Δ -10.3%, P < 0.001), and right atrial area (Δ -8.2%, P < 0.001). After 8 wk of detraining, there was a significant reduction in right ventricle chamber size (end-diastolic area Δ = -8.0%, P < 0.05) without further concomitant reductions in PV or LV wall thickness. Abrupt reductions in exercise training stimulus result in a structure-specific time course of reverse cardiac remodeling that occurs largely independently of PV contraction. NEW & NOTEWORTHY Significant reverse cardiac remodeling, previously documented among competitive athletes, extends to recreational runners and occurs with a distinct time course. Initial reductions in plasma volume and left ventricular (LV) mass, driven by reductions in wall thickness, are followed by contraction of the right ventricle. Consistent with data from competitive athletes, LV chamber volumes appear less responsive to detraining and may be a more permanent adaptation to sport.
PID Serval
serval:BIB_9EB7BC9F77BC
PMID
Open Access
Oui
Date de création
2022-12-07T10:03:10.206Z
Date de création dans IRIS
2025-05-20T22:10:27Z