Titre
The role of chemotherapy in patients with established gastric cancer.
Type
article
Institution
Externe
Auteur(s)
Wagner, A.D.
Auteure/Auteur
Schneider, P.M.
Auteure/Auteur
Fleig, W.E.
Auteure/Auteur
Liens vers les personnes
ISSN
1521-6918
Statut éditorial
Publié
Date de publication
2006
Volume
20
Numéro
4
Première page
789
Dernière page/numéro d’article
799
Peer-reviewed
Oui
Langue
anglais
Résumé
Chemotherapy significantly improves survival in comparison to best supportive care in patients with metastasised gastric cancer. In patients for whom a three-drug-combination is considered as the treatment of choice, ECF (epirubicin, cisplatin and 5-FU as a continuous infusion) should be regarded as standard of care. However, results for ECF have been challenged by the recently presented REAL-2-trial, which demonstrated a significant survival benefit for EOX (epirubicin, oxaliplatin, capecitabine) over ECF. Adjuvant 5-FU-based chemoradiation should be discussed in patients with inadequate lymphadenectomy, but is not internationally accepted as standard of care: whether patients with adequate lymhphadenectomy benefit from adjuvant chemoradiotherapy is currently unclear. According to the results of the UK MAGIC trial, perioperative treatment with ECF (3 cycles prior to and post surgery) results in a significantly reduced risk of death for patients with resectable gastric cancer as compared to surgery alone. Neo-adjuvant chemotherapy has the ability to downsize gastric tumours and appears to improve R0-resection rates, but its potential to improve overall survival is still unclear.
PID Serval
serval:BIB_6D5F8B57D8F5
PMID
Date de création
2016-02-02T16:40:14.942Z
Date de création dans IRIS
2025-05-20T23:59:34Z