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  4. Electronic Nicotine-Delivery Systems for Smoking Cessation.
 
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Titre

Electronic Nicotine-Delivery Systems for Smoking Cessation.

Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
New England Journal of Medicine  
Auteur(s)
Auer, R.
Auteure/Auteur
Schoeni, A.
Auteure/Auteur
Humair, J.P.
Auteure/Auteur
Jacot-Sadowski, I.
Auteure/Auteur
Berlin, I.
Auteure/Auteur
Stuber, M.J.
Auteure/Auteur
Haller, M.L.
Auteure/Auteur
Tango, R.C.
Auteure/Auteur
Frei, A.
Auteure/Auteur
Strassmann, A.
Auteure/Auteur
Bruggmann, P.
Auteure/Auteur
Baty, F.
Auteure/Auteur
Brutsche, M.
Auteure/Auteur
Tal, K.
Auteure/Auteur
Baggio, S.
Auteure/Auteur
Jakob, J.
Auteure/Auteur
Sambiagio, N.
Auteure/Auteur
Hopf, N.B.
Auteure/Auteur
Feller, M.
Auteure/Auteur
Rodondi, N.
Auteure/Auteur
Berthet, A.
Auteure/Auteur
Liens vers les personnes
Berthet, Aurélie  
Jacot Sadowski, Isabelle  
Hopf, Nancy  
Berlin, Ivan  
Liens vers les unités
PMU/UNISANTE  
ISSN
1533-4406
Statut éditorial
Publié
Date de publication
2024-02-15
Volume
390
Numéro
7
Première page
601
Dernière page/numéro d’article
610
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Electronic nicotine-delivery systems - also called e-cigarettes - are used by some tobacco smokers to assist with quitting. Evidence regarding the efficacy and safety of these systems is needed.
In this open-label, controlled trial, we randomly assigned adults who were smoking at least five tobacco cigarettes per day and who wanted to set a quit date to an intervention group, which received free e-cigarettes and e-liquids, standard-of-care smoking-cessation counseling, and optional (not free) nicotine-replacement therapy, or to a control group, which received standard counseling and a voucher, which they could use for any purpose, including nicotine-replacement therapy. The primary outcome was biochemically validated, continuous abstinence from smoking at 6 months. Secondary outcomes included participant-reported abstinence from tobacco and from any nicotine (including smoking, e-cigarettes, and nicotine-replacement therapy) at 6 months, respiratory symptoms, and serious adverse events.
A total of 1246 participants underwent randomization; 622 participants were assigned to the intervention group, and 624 to the control group. The percentage of participants with validated continuous abstinence from tobacco smoking was 28.9% in the intervention group and 16.3% in the control group (relative risk, 1.77; 95% confidence interval, 1.43 to 2.20). The percentage of participants who abstained from smoking in the 7 days before the 6-month visit was 59.6% in the intervention group and 38.5% in the control group, but the percentage who abstained from any nicotine use was 20.1% in the intervention group and 33.7% in the control group. Serious adverse events occurred in 25 participants (4.0%) in the intervention group and in 31 (5.0%) in the control group; adverse events occurred in 272 participants (43.7%) and 229 participants (36.7%), respectively.
The addition of e-cigarettes to standard smoking-cessation counseling resulted in greater abstinence from tobacco use among smokers than smoking-cessation counseling alone. (Funded by the Swiss National Science Foundation and others; ESTxENDS ClinicalTrials.gov number, NCT03589989.).
PID Serval
serval:BIB_E347635FBAFC
DOI
10.1056/NEJMoa2308815
PMID
38354139
WOS
001191109500007
Permalien
https://iris.unil.ch/handle/iris/247582
Date de création
2024-02-15T15:30:34.461Z
Date de création dans IRIS
2025-05-21T06:23:34Z
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