Titre
At the Bench: Pre-clinical evidence for multiple functions of CXCR4 in cancer.
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Luker, G.D.
Auteure/Auteur
Yang, J.
Auteure/Auteur
Richmond, A.
Auteure/Auteur
Scala, S.
Auteure/Auteur
Festuccia, C.
Auteure/Auteur
Schottelius, M.
Auteure/Auteur
Wester, H.J.
Auteure/Auteur
Zimmermann, J.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1938-3673
Statut éditorial
Publié
Date de publication
2021-05
Volume
109
Numéro
5
Première page
969
Dernière page/numéro d’article
989
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Publication Status: ppublish
Résumé
Signaling through chemokine receptor, C-X-C chemokine receptor type 4 (CXCR4) regulates essential processes in normal physiology, including embryogenesis, tissue repair, angiogenesis, and trafficking of immune cells. Tumors co-opt many of these fundamental processes to directly stimulate proliferation, invasion, and metastasis of cancer cells. CXCR4 signaling contributes to critical functions of stromal cells in cancer, including angiogenesis and multiple cell types in the tumor immune environment. Studies in animal models of several different types of cancers consistently demonstrate essential functions of CXCR4 in tumor initiation, local invasion, and metastasis to lymph nodes and distant organs. Data from animal models support clinical observations showing that integrated effects of CXCR4 on cancer and stromal cells correlate with metastasis and overall poor prognosis in >20 different human malignancies. Small molecules, Abs, and peptidic agents have shown anticancer efficacy in animal models, sparking ongoing efforts at clinical translation for cancer therapy. Investigators also are developing companion CXCR4-targeted imaging agents with potential to stratify patients for CXCR4-targeted therapy and monitor treatment efficacy. Here, pre-clinical studies demonstrating functions of CXCR4 in cancer are reviewed.
PID Serval
serval:BIB_55863C1885F3
PMID
Date de création
2020-11-02T11:52:05.750Z
Date de création dans IRIS
2025-05-20T16:07:35Z