Titre
Molecular physiology of glucose transporters.
Type
synthèse (review)
Institution
Externe
Périodique
Auteur(s)
Thorens, B.
Auteure/Auteur
Charron, M.J.
Auteure/Auteur
Lodish, H.F.
Auteure/Auteur
Liens vers les personnes
ISSN
0149-5992[print], 0149-5992[linking]
Statut éditorial
Publié
Date de publication
1990-03
Volume
13
Numéro
3
Première page
209
Dernière page/numéro d’article
218
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review
Publication Status: ppublish
Publication Status: ppublish
Résumé
Molecular cloning of cDNA encoding the human erythrocyte facilitated-diffusion glucose transporter (GT) has elucidated its structure and has permitted a careful study of its tissue distribution and of its involvement in processes such as insulin-stimulated glucose uptake by adipose cells or transformation-induced increase in glucose metabolism. An important outcome of these studies was the discovery that additional isoforms of this transporter were expressed in a tissue-specific manner; these comprise a family of structurally and functionally related molecules. Their tissue distribution, differences in kinetic properties, and differential regulation by ambient glucose and insulin levels suggest that they play specific roles in the control of glucose homeostasis. Herein, we will discuss the structure of three members of the GT family: erythroid/brain GT, liver GT, and adipose cell/muscle GT. In the light of their tissue-specific expression, kinetic parameters, and susceptibility to insulin action, we discuss their possible specific functions.
PID Serval
serval:BIB_0B1D27EB92A7
PMID
Date de création
2008-01-24T12:41:42.570Z
Date de création dans IRIS
2025-05-20T18:04:50Z