Titre
Photoreactivation of cyclobutane dimers and (6-4) photoproducts in the epidermis of the marsupial, Monodelphis domestica
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Mitchell, D. L.
Auteure/Auteur
Applegate, L. A.
Auteure/Auteur
Nairn, R. S.
Auteure/Auteur
Ley, R. D.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0031-8655
Statut éditorial
Publié
Date de publication
1990
Volume
51
Numéro
6
Première page
653
Dernière page/numéro d’article
658
Notes
DA - 19900813
LA - eng
PT - Journal Article
PT - Research Support, Non-U.S. Gov't
PT - Research Support, U.S. Gov't, Non-P.H.S
PT - Research Support, U.S. Gov't, P.H.S
RN - 0 (Pyrimidine Dimers)
RN - 9007-49-2 (DNA)
SB - IM
LA - eng
PT - Journal Article
PT - Research Support, Non-U.S. Gov't
PT - Research Support, U.S. Gov't, Non-P.H.S
PT - Research Support, U.S. Gov't, P.H.S
RN - 0 (Pyrimidine Dimers)
RN - 9007-49-2 (DNA)
SB - IM
Résumé
Radioimmunoassays were used to investigate the repair of cyclobutane pyrimidine dimers and pyrimidine (6-4)pyrimidone photoproducts ((6-4] photoproducts) in the epidermis of the South American opossum, Monodelphis domestica. In the absence of photoreactivating light, both types of photodamage were excised with similar kinetics, 50% of the damage remaining 8 h after UV irradiation in vivo. Exposure of UV-irradiated skin to photoreactivating light resulted in removal of most of the cyclobutane dimers and an enhanced rate of (6-4) photoproduct repair. Photoenhanced excision repair of non-dimer damage increases the range of biologically effective lesions removed by in vivo photoreactivation
Sujets
PID Serval
serval:BIB_E0EA0C197E28
PMID
Date de création
2008-02-18T16:24:14.401Z
Date de création dans IRIS
2025-05-21T00:56:11Z