Titre
Deterioration of renal function in hypertensive patients with scleroderma despite blood pressure normalization with captopril.
Type
étude de cas
Institution
Externe
Périodique
Auteur(s)
Waeber, B.
Auteure/Auteur
Schaller, M.D.
Auteure/Auteur
Wauters, J.P.
Auteure/Auteur
Brunner, H.R.
Auteure/Auteur
Liens vers les personnes
ISSN
0023-2173
Statut éditorial
Publié
Date de publication
1984
Volume
62
Numéro
15
Première page
728
Dernière page/numéro d’article
730
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
The orally active angiotensin-converting enzyme inhibitor captopril was administered for up to 11 weeks to three patients with progressive systemic sclerosis presenting with hypertension and plasma creatinine levels of 3.1, 7.2 and 10.4 mg/100 ml. Only one patient had malignant phase hypertension. In this patient a diuretic had to be added to captopril in order to keep blood pressure under control. Despite sustained blood pressure control during captopril administration, renal function deteriorated and hemodialysis treatment had to be started in all patients. Up to that time no substantial improvement in skin lesions was observed. During the period of dialysis, blood pressure was normal in all patients even though administration of captopril was discontinued. All three patients died of respiratory failure while on chronic hemodialysis for 3 to 4 weeks. These observations confirm that angiotensin-converting enzyme inhibition may be helpful in controlling blood pressure of patients with scleroderma. However, in contrast to some earlier reports, they also indicate that converting enzyme inhibition does not always prevent the multivisceral vascular lesions of scleroderma.
PID Serval
serval:BIB_12810A7FAFDE
PMID
Date de création
2011-09-06T16:15:04.249Z
Date de création dans IRIS
2025-05-20T19:31:33Z