Titre
Do Infectious Diseases After Kidney Retransplantation Differ From Those After First Kidney Transplantation?
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Kusejko, K.
Auteure/Auteur
Neofytos, D.
Auteure/Auteur
van Delden, C.
Auteure/Auteur
Hirsch, H.H.
Auteure/Auteur
Meylan, P.
Auteure/Auteur
Boggian, K.
Auteure/Auteur
Hirzel, C.
Auteure/Auteur
Garzoni, C.
Auteure/Auteur
Sidler, D.
Auteure/Auteur
Schnyder, A.
Auteure/Auteur
Schaub, S.
Auteure/Auteur
Golshayan, D.
Auteure/Auteur
Haidar, F.
Auteure/Auteur
Bonani, M.
Auteure/Auteur
Kouyos, R.D.
Auteure/Auteur
Mueller, N.J.
Auteure/Auteur
Schreiber, P.W.
Auteure/Auteur
Contributrices/contributeurs
Amico, P.
Aubert, J.D.
Banz, V.
Beckmann, S.
Beldi, G.
Berger, C.
Berishvili, E.
Berzigotti, A.
Binet, I.
Bochud, P.Y.
Branca, S.
Bucher, H.
Catana, E.
Cairoli, A.
Chalandon, Y.
De Geest, S.
De Rougemont, O.
De Seigneux, S.
Dickenmann, M.
Dreifuss, J.L.
Duchosal, M.
Fehr, T.
Ferrari-Lacraz, S.
Garzoni, C.
Golshayan, D.
Goossens, N.
Halter, FHJ
Heim, D.
Hess, C.
Hillinger, S.
Hirsch, H.H.
Hirt, P.
Hofbauer, G.
Huynh-Do, U.
Immer, F.
Koller, M.
Laager, M.
Laesser, B.
Lamoth, F.
Lehmann, R.
Leichtle, A.
Manuel, O.
Marti, H.P.
Martinelli, M.
McLin, V.
Mellac, K.
Merçay, A.
Mettler, K.
Müller, A.
Mueller, N.J.
Müller-Arndt, U.
Müllhaupt, B.
Nägeli, M.
Oldani, G.
Pascual, M.
Passweg, J.
Pazeller, R.
Posfay-Barbe, K.
Rick, J.
Rosselet, A.
Rossi, S.
Rothlin, S.
Ruschitzka, F.
Schachtner, T.
Schanz, U.
Schaub, S.
Scherrer, A.
Schnyder, A.
Schuurmans, M.
Schwab, S.
Sengstag, T.
Simonetta, F.
Stampf, S.
Steiger, J.
Stirnimann, G.
Stürzinger, U.
Van Delden, C.
Venetz, J.P.
Villard, J.
Vionnet, J.
Wick, M.
Wilhelm, M.
Yerly, P.
Groupes de travail
Swiss Transplant Cohort Study
Liens vers les personnes
Liens vers les unités
ISSN
2328-8957
Statut éditorial
Publié
Date de publication
2024-03
Volume
11
Numéro
3
Première page
ofae055
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Résumé
Infectious diseases (IDs) are highly relevant after solid organ transplantation in terms of morbidity and mortality, being among the most common causes of death. Patients undergoing kidney retransplantation (re-K-Tx) have been already receiving immunosuppressive therapy over a prolonged period, potentially facilitating subsequent infections. Comparing ID events after re-K-Tx and first kidney transplantation (f-K-Tx) can delineate patterns and risks of ID events associated with prolonged immunosuppression.
We included adult patients with records on f-K-Tx and re-K-Tx in the Swiss Transplant Cohort Study. We analyzed ID events after f-K-Tx and re-K-Tx within the same patients and compared infection rates, causative pathogens, and infection sites. Recurrent time-to-event analyses were performed for comparison of infection rates.
A total of 59 patients with a median age of 47 years (range, 18-73) were included. Overall, 312 ID events in 52 patients occurred. In multivariable recurrent event modeling, the rate of ID events was significantly lower after re-K-Tx (hazard ratio, 0.70; P = .02). More bacterial (68.9% vs 60.4%) and fungal (4.0% vs 1.1%) infections were observed after f-K-Tx but fewer viral infections (27.0% vs 38.5%) as compared with re-K-Tx (P = .11). After f-K-Tx, urinary and gastrointestinal tract infections were more frequent; after re-K-Tx, respiratory tract and surgical site infections were more frequent (P < .001).
ID events were less frequent after re-K-Tx. Affected sites differed significantly after f-K-Tx vs re-K-Tx.
We included adult patients with records on f-K-Tx and re-K-Tx in the Swiss Transplant Cohort Study. We analyzed ID events after f-K-Tx and re-K-Tx within the same patients and compared infection rates, causative pathogens, and infection sites. Recurrent time-to-event analyses were performed for comparison of infection rates.
A total of 59 patients with a median age of 47 years (range, 18-73) were included. Overall, 312 ID events in 52 patients occurred. In multivariable recurrent event modeling, the rate of ID events was significantly lower after re-K-Tx (hazard ratio, 0.70; P = .02). More bacterial (68.9% vs 60.4%) and fungal (4.0% vs 1.1%) infections were observed after f-K-Tx but fewer viral infections (27.0% vs 38.5%) as compared with re-K-Tx (P = .11). After f-K-Tx, urinary and gastrointestinal tract infections were more frequent; after re-K-Tx, respiratory tract and surgical site infections were more frequent (P < .001).
ID events were less frequent after re-K-Tx. Affected sites differed significantly after f-K-Tx vs re-K-Tx.
PID Serval
serval:BIB_0BE70CAAD5F0
PMID
Open Access
Oui
Date de création
2024-03-14T16:12:45.240Z
Date de création dans IRIS
2025-05-20T14:21:33Z
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Nom
38464489_BIB_0BE70CAAD5F0.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by/4.0
Taille
1.11 MB
Format
Adobe PDF
PID Serval
serval:BIB_0BE70CAAD5F0.P001
URN
urn:nbn:ch:serval-BIB_0BE70CAAD5F03
Somme de contrôle
(MD5):7c2e14c804b49c6b4bd3ab8abef45791