Titre
Immunological pathogenesis of main age-related diseases and frailty: Role of immunosenescence.
Type
synthèse (review)
Institution
Externe
Périodique
Auteur(s)
Lang, PO
Auteure/Auteur
Mitchell, W
Auteure/Auteur
Lapenna, A
Auteure/Auteur
Pitts, D
Auteure/Auteur
Aspinall, R.
Auteure/Auteur
Liens vers les personnes
ISSN
1878-7649
Statut éditorial
Publié
Date de publication
2010
Volume
1
Numéro
2
Première page
112
Dernière page/numéro d’article
21
Peer-reviewed
Oui
Langue
anglais
Résumé
Nowadays, it is well known that with advancing age individuals are at an increased susceptibility to develop diseases such as Alzheimer's disease, infectious diseases, cancer, and osteoporosis. Ageing is associated with various changes in immune parameters: therefore many authors have postulated that these age-related diseases could be explained, at least in part, by an overall deregulation of the function of the immune system. Immunosenescence is the term usually used to describe the acquired dysfunctional immunity within the ageing population affecting both innate and adaptive immunity. The present review examines the close involvement of the immunosenescence in the pathogenesis of these main age-related clinical outcomes, insulin resistance and the frailty process.
PID Serval
serval:BIB_BD9C72C19FE4
Date de création
2015-04-15T08:36:09.406Z
Date de création dans IRIS
2025-05-21T02:56:45Z