Titre
Prolonged Maternal Zika Viremia as a Marker of Adverse Perinatal Outcomes.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Pomar, L.
Auteure/Auteur
Lambert, V.
Auteure/Auteur
Matheus, S.
Auteure/Auteur
Pomar, C.
Auteure/Auteur
Hcini, N.
Auteure/Auteur
Carles, G.
Auteure/Auteur
Rousset, D.
Auteure/Auteur
Vouga, M.
Auteure/Auteur
Panchaud, A.
Auteure/Auteur
Baud, D.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1080-6059
Statut éditorial
Publié
Date de publication
2021-02
Volume
27
Numéro
2
Première page
490
Dernière page/numéro d’article
498
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
Whether prolonged maternal viremia after Zika virus infection represents a risk factor for maternal-fetal transmission and subsequent adverse outcomes remains unclear. In this prospective cohort study in French Guiana, we enrolled Zika virus-infected pregnant women with a positive PCR result at inclusion and noninfected pregnant women; both groups underwent serologic testing in each trimester and at delivery during January-July 2016. Prolonged viremia was defined as ongoing virus detection >30 days postinfection. Adverse outcomes (fetal loss or neurologic anomalies) were more common in fetuses and neonates from mothers with prolonged viremia (40.0%) compared with those from infected mothers without prolonged viremia (5.3%, adjusted relative risk [aRR] 7.2 [95% CI 0.9-57.6]) or those from noninfected mothers (6.6%, aRR 6.7 [95% CI 3.0-15.1]). Congenital infections were confirmed more often in fetuses and neonates from mothers with prolonged viremia compared with the other 2 groups (60.0% vs. 26.3% vs. 0.0%, aRR 2.3 [95% CI 0.9-5.5]).
PID Serval
serval:BIB_1464F23F2CD5
PMID
Open Access
Oui
Date de création
2021-04-16T17:23:43.959Z
Date de création dans IRIS
2025-05-20T17:41:06Z
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Nom
33496246_BIB_1464F23F2CD5.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by/4.0
Taille
2.1 MB
Format
Adobe PDF
PID Serval
serval:BIB_1464F23F2CD5.P001
URN
urn:nbn:ch:serval-BIB_1464F23F2CD58
Somme de contrôle
(MD5):77f2f2f54c62df1ec7afde8eafd86257