Titre
Inability of serial fibrin monomer measurements to predict or exclude deep venous thrombosis in asymptomatic patients undergoing total knee arthroplasty
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Reber, G.
Auteure/Auteur
Blanchard, J.
Auteure/Auteur
Bounameaux, H.
Auteure/Auteur
Hoffmeyer, P.
Auteure/Auteur
Miron, M. J.
Auteure/Auteur
Leyvraz, P. F.
Auteure/Auteur
de Moerloose, P.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0957-5235
Statut éditorial
Publié
Date de publication
2000-04
Volume
11
Numéro
3
Première page
305
Dernière page/numéro d’article
8
Notes
Journal Article --- Old month value: Apr
Résumé
Fibrin monomer (FM) is a highly sensitive marker of venous thromboembolism and can be used to rule out deep venous thrombosis (DVT) and/or pulmonary embolism in symptomatic outpatients. The aim of the study was to investigate the usefulness of serial fibrin monomer determinations to predict or rule out DVT after total knee arthroplasty in asymptomatic patients. One hundred and thirty consecutive patients underwent total knee replacement. Blood samples were obtained in 104 of them the day before, at days 1, 3, 6 after surgery and at the day of phlebography. Phlebography was performed in all these patients between days 8 and 12 after surgery. There were 44 DVT (44/104, 42%). As compared with the patients without DVT, FM mean levels were 2 and 1.5 times higher in the DVT group at day 3 (P < 0.001) and day 6 (P < 0.01), respectively. However, no useful cut-off values for DVT prediction or exclusion could be determined due to the scattering of the values. Therefore, despite differences between patients with or without DVT, serial FM determinations are of no value for predicting or ruling out DVT in individual patients undergoing total knee arthroplasty.
Sujets
PID Serval
serval:BIB_6B0635747E3F
PMID
Date de création
2008-01-28T11:22:46.697Z
Date de création dans IRIS
2025-05-20T23:25:44Z