Titre
The neuropeptide VIP modulates the neurotransmitter phenotype of cultured chick sympathetic neurons
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Beretta, C.
Auteure/Auteur
Zurn, A. D.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0012-1606
Statut éditorial
Publié
Date de publication
1991-11
Volume
148
Numéro
1
Première page
87
Dernière page/numéro d’article
94
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Nov
Research Support, Non-U.S. Gov't --- Old month value: Nov
Résumé
The present report provides evidence for a novel function for the neuropeptide vasoactive intestinal peptide (VIP). We demonstrate that VIP increases the cholinergic and the noradrenergic properties of cultured chick sympathetic neurons without changing neuronal survival and metabolism. VIP induces a 10- to 15-fold increase in the activity of choline acetyltransferase and an approximately twofold increase in the activity of tyrosine hydroxylase. Forskolin, an activator of adenylate cyclase, mimics all the effects of VIP on these cells. In addition, the effects of forskolin and VIP at optimal concentrations are not additive. Furthermore, VIP induces a rapid increase in the intracellular cAMP levels. Thus VIP acts via a cAMP-dependent pathway to enhance the cholinergic and noradrenergic properties of cultured chick sympathetic neurons.
Sujets
PID Serval
serval:BIB_EEEA92AE899D
PMID
Date de création
2008-01-28T07:44:15.569Z
Date de création dans IRIS
2025-05-21T06:42:55Z