Titre
Mutations in the basal core promoter and precore/core gene of hepatitis B virus in patients with chronic active but not acute hepatitis B
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Auteur(s)
Mayerat, C.
Auteure/Auteur
Mantegani, A.
Auteure/Auteur
Spertini, F.
Auteure/Auteur
Frei, P. C.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0934-9723
Statut éditorial
Publié
Date de publication
1999-12
Volume
18
Numéro
12
Première page
871
Dernière page/numéro d’article
8
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Dec
Research Support, Non-U.S. Gov't --- Old month value: Dec
Résumé
Around 5-10% of adults infected with hepatitis B virus (HBV) develop a chronic liver disease such as chronic active hepatitis (CAH), and it is unclear whether the clinical outcome depends solely on the immune response or whether viral factors also play a role. In this study, a search was therefore made for nucleotide mutations in the basic core promoter (BCP) and amino-acid substitutions in the precore/core region of HBV infecting patients with CAH or with acute hepatitis. The nucleotide sequences of the BCP and of the precore/core region were determined in virus from ten patients with CAH and ten with acute hepatitis. The precore/core sequences were also analysed in 14 additional patients (6 with CAH, 8 with acute hepatitis). In seven of the ten patients with CAH, five types of mutations were found in the BCP. Deletions in the precore/core region were observed in six patients. In all six patients where only the precore/core region was studied, amino-acid substitutions were present. In contrast, in the ten patients with acute hepatitis studied for BCP, a mutation was found in the BCP of one patient only. Of the 18 patients in whom the precore/core was studied, three had an amino-acid substitution in this region. The results show a clear link between CAH and both HBV BCP and precore/core region mutations, suggesting these mutations may play a role in the persistence of HBV infection.
Sujets
PID Serval
serval:BIB_DBE82CB2C8C7
PMID
Date de création
2008-01-25T14:20:09.462Z
Date de création dans IRIS
2025-05-21T06:53:50Z