Titre
Advanced MRI unravels the nature of tissue alterations in early multiple sclerosis.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Auteur(s)
Bonnier, G.
Auteure/Auteur
Roche, A.
Auteure/Auteur
Romascano, D.
Auteure/Auteur
Simioni, S.
Auteure/Auteur
Meskaldji, D.
Auteure/Auteur
Rotzinger, D.
Auteure/Auteur
Lin, Y.C.
Auteure/Auteur
Menegaz, G.
Auteure/Auteur
Schluep, M.
Auteure/Auteur
Du Pasquier, R.
Auteure/Auteur
Sumpf, T.J.
Auteure/Auteur
Frahm, J.
Auteure/Auteur
Thiran, J.P.
Auteure/Auteur
Krueger, G.
Auteure/Auteur
Granziera, C.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
2328-9503
Statut éditorial
Publié
Date de publication
2014-06
Volume
1
Numéro
6
Première page
423
Dernière page/numéro d’article
432
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types:
Publication Status: ppublish
Publication Status: ppublish
Résumé
INTRODUCTION: In patients with multiple sclerosis (MS), conventional magnetic resonance imaging (MRI) provides only limited insights into the nature of brain damage with modest clinic-radiological correlation. In this study, we applied recent advances in MRI techniques to study brain microstructural alterations in early relapsing-remitting MS (RRMS) patients with minor deficits. Further, we investigated the potential use of advanced MRI to predict functional performances in these patients.
METHODS: Brain relaxometry (T1, T2, T2*) and magnetization transfer MRI were performed at 3T in 36 RRMS patients and 18 healthy controls (HC). Multicontrast analysis was used to assess for microstructural alterations in normal-appearing (NA) tissue and lesions. A generalized linear model was computed to predict clinical performance in patients using multicontrast MRI data, conventional MRI measures as well as demographic and behavioral data as covariates.
RESULTS: Quantitative T2 and T2* relaxometry were significantly increased in temporal normal-appearing white matter (NAWM) of patients compared to HC, indicating subtle microedema (P = 0.03 and 0.004). Furthermore, significant T1 and magnetization transfer ratio (MTR) variations in lesions (mean T1 z-score: 4.42 and mean MTR z-score: -4.09) suggested substantial tissue loss. Combinations of multicontrast and conventional MRI data significantly predicted cognitive fatigue (P = 0.01, Adj-R (2) = 0.4), attention (P = 0.0005, Adj-R (2) = 0.6), and disability (P = 0.03, Adj-R (2) = 0.4).
CONCLUSION: Advanced MRI techniques at 3T, unraveled the nature of brain tissue damage in early MS and substantially improved clinical-radiological correlations in patients with minor deficits, as compared to conventional measures of disease.
METHODS: Brain relaxometry (T1, T2, T2*) and magnetization transfer MRI were performed at 3T in 36 RRMS patients and 18 healthy controls (HC). Multicontrast analysis was used to assess for microstructural alterations in normal-appearing (NA) tissue and lesions. A generalized linear model was computed to predict clinical performance in patients using multicontrast MRI data, conventional MRI measures as well as demographic and behavioral data as covariates.
RESULTS: Quantitative T2 and T2* relaxometry were significantly increased in temporal normal-appearing white matter (NAWM) of patients compared to HC, indicating subtle microedema (P = 0.03 and 0.004). Furthermore, significant T1 and magnetization transfer ratio (MTR) variations in lesions (mean T1 z-score: 4.42 and mean MTR z-score: -4.09) suggested substantial tissue loss. Combinations of multicontrast and conventional MRI data significantly predicted cognitive fatigue (P = 0.01, Adj-R (2) = 0.4), attention (P = 0.0005, Adj-R (2) = 0.6), and disability (P = 0.03, Adj-R (2) = 0.4).
CONCLUSION: Advanced MRI techniques at 3T, unraveled the nature of brain tissue damage in early MS and substantially improved clinical-radiological correlations in patients with minor deficits, as compared to conventional measures of disease.
PID Serval
serval:BIB_CA5C2B672057
PMID
Open Access
Oui
Date de création
2014-12-15T13:04:16.195Z
Date de création dans IRIS
2025-05-21T02:00:05Z
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Nom
BIB_CA5C2B672057.P001.pdf
Version du manuscrit
preprint
Taille
1.23 MB
Format
Adobe PDF
PID Serval
serval:BIB_CA5C2B672057.P001
URN
urn:nbn:ch:serval-BIB_CA5C2B6720570
Somme de contrôle
(MD5):6a689171d6e37f054fdc2a48d9158276