Titre
Albendazole treatment of echinococcosis in humans: effects on microsomal metabolism and drug tolerance
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Steiger, U.
Auteure/Auteur
Cotting, J.
Auteure/Auteur
Reichen, J.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0009-9236
Statut éditorial
Publié
Date de publication
1990-03
Volume
47
Numéro
3
Première page
347
Dernière page/numéro d’article
53
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Mar
Research Support, Non-U.S. Gov't --- Old month value: Mar
Résumé
We prospectively studied the effect of albendazole on microsomal reserve and on first-pass activation to albendazole sulfoxide in patients with hydatid disease. An aminopyrine breath test was performed in 12 patients while they were receiving albendazole treatment and while they were not. Excretion of 14CO2 in breath averaged 0.70%.kg.mmol-1 +/- 0.20%.kg.mmol-1 without treatment and 0.54%.kg.mmol-1 +/- 0.14%.kg.mmol-1 with treatment (p less than 0.005). Plasma levels of albendazole sulfoxide were measured 4 hours after the morning dose during the first and second half of the 4-week treatment cycles. In nine of the 12 patients albendazole sulfoxide levels decreased during the second half of the cycle by an average of 0.84 +/- 0.76 mumol/L (p less than 0.02). Transaminase levels increased in 10 of the 12 patients during long-term albendazole treatment, and major side effects, including hepatotoxicity, neutropenia, and alopecia, were observed in three patients. We conclude that albendazole partially inhibits microsomal enzyme function but induces its own metabolism. Hepatotoxicity and other possible severe side effects necessitate close therapeutic monitoring of patients who are given albendazole.
Sujets
PID Serval
serval:BIB_909395BCDE22
PMID
Date de création
2008-01-24T15:41:34.901Z
Date de création dans IRIS
2025-05-21T01:45:27Z