Titre
Contribution de l'étude CoLaus à l'élucidation des déterminants de l'acide urique sérique. [Contribution of the CoLaus study to decipher the determinants of serum uric acid].
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Bochud, Murielle
Auteure/Auteur
Vollenweider, Peter
Auteure/Auteur
Waeber, Gérard
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1660-9379
Statut éditorial
Publié
Date de publication
2011
Volume
7
Numéro
315
Première page
2142
Langue
français
Résumé
Asymptomatic hyperuricemia affects one in five adults in the general population and is associated with elevated cardiovascular risk. It is however not clear whether asymptomatic hyperuricemia is a cause or simply a marker of conditions associated with high cardiovascular risk. Sex, age, obesity, renal function and selected drugs are major determinants of serum uric acid. Moreover, recent genome-wide association studies have identified new genes involved in the control of serum uric acid levels, in particular SLC2A9, which encodes a urate transporter located in the kidney. A genetic score based on several genetic variants associated with serum uric acid is strongly associated with the risk of gout, but not with cardiovascular events so far.
PID Serval
serval:BIB_474E8F7C5646
PMID
Date de création
2011-11-07T12:36:42.720Z
Date de création dans IRIS
2025-05-20T14:09:25Z
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BIB_474E8F7C5646.P001.pdf
Version du manuscrit
preprint
Taille
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Format
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Somme de contrôle
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