Titre
Prevalence of renal impairment and its association with cardiovascular risk factors in a general population: results of the Swiss SAPALDIA study
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Nitsch, D.
Auteure/Auteur
Felber Dietrich, D.
Auteure/Auteur
von Eckardstein, A.
Auteure/Auteur
Gaspoz, J. M.
Auteure/Auteur
Downs, S. H.
Auteure/Auteur
Leuenberger, P.
Auteure/Auteur
Tschopp, J. M.
Auteure/Auteur
Brandli, O.
Auteure/Auteur
Keller, R.
Auteure/Auteur
Gerbase, M. W.
Auteure/Auteur
Probst-Hensch, N. M.
Auteure/Auteur
Stutz, E. Z.
Auteure/Auteur
Ackermann-Liebrich, U.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0931-0509
Statut éditorial
Publié
Date de publication
2006-04
Volume
21
Numéro
4
Première page
935
Dernière page/numéro d’article
44
Notes
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't --- Old month value: Apr
Randomized Controlled Trial
Research Support, Non-U.S. Gov't --- Old month value: Apr
Résumé
BACKGROUND: Impaired renal function is evolving as an independent marker of the risk of cardiovascular morbidity and mortality. Little is known about the prevalence of impaired renal function and its relationship to cardiovascular risk factors in the Swiss general population. METHODS: SAPALDIA comprises a random sample of the Swiss population established in 1991, originally to investigate the health effects of long-term exposure to air pollution. Participants were reassessed in 2002/3 and blood measurements were obtained (n = 6317). Renal function was estimated using the Cockcroft-Gault equation and the modified MDRD (four-component) equation incorporating age, race, gender and serum creatinine level. RESULTS: The estimated prevalence of impaired renal function [estimated glomerular filtration rate <60 ml/min/1.73 m(2)] differed substantially between men and women, particularly at higher ages, and amounted to 13% [95% confidence interval (CI) 10-16%] and 36% (95% CI 32-40%) in men and women, respectively, of 65 years or older. Smoking, obesity, blood lipid levels, high systolic blood pressure and hyperuricaemia were all more common in men when compared with women. These cardiovascular risk factors were also associated independently with creatinine in both women and men. Women were less likely to receive cardiovascular drugs, in particular angiotensin-converting enzyme inhibitors and beta-blockers, when compared with men of the same age. CONCLUSION: Moderate renal impairment seems to be prevalent in the general population, with an apparent excess in females which is not explained by conventional cardiovascular risk factors. The unexpected finding questions the validity of the prediction equations, in particular in females.
Sujets
PID Serval
serval:BIB_9CB899C36F58
PMID
Open Access
Oui
Date de création
2008-01-25T08:50:15.201Z
Date de création dans IRIS
2025-05-21T03:50:40Z
Fichier(s)![Vignette d'image]()
En cours de chargement...
Nom
REF.pdf
Version du manuscrit
published
Taille
171.04 KB
Format
Adobe PDF
PID Serval
serval:BIB_9CB899C36F58.P001
URN
urn:nbn:ch:serval-BIB_9CB899C36F587
Somme de contrôle
(MD5):1715ebbb0d3a2ba6f73416b3358e52c7