Titre
The molecular basis, genetic control and pleiotropic effects of local gene co-expression.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Ribeiro, D.M.
Auteure/Auteur
Rubinacci, S.
Auteure/Auteur
Ramisch, A.
Auteure/Auteur
Hofmeister, R.J.
Auteure/Auteur
Dermitzakis, E.T.
Auteure/Auteur
Delaneau, O.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
2041-1723
Statut éditorial
Publié
Date de publication
2021-08-10
Volume
12
Numéro
1
Première page
4842
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Publication Status: epublish
Résumé
Nearby genes are often expressed as a group. Yet, the prevalence, molecular mechanisms and genetic control of local gene co-expression are far from being understood. Here, by leveraging gene expression measurements across 49 human tissues and hundreds of individuals, we find that local gene co-expression occurs in 13% to 53% of genes per tissue. By integrating various molecular assays (e.g. ChIP-seq and Hi-C), we estimate the ability of several mechanisms, such as enhancer-gene interactions, in distinguishing gene pairs that are co-expressed from those that are not. Notably, we identify 32,636 expression quantitative trait loci (eQTLs) which associate with co-expressed gene pairs and often overlap enhancer regions. Due to affecting several genes, these eQTLs are more often associated with multiple human traits than other eQTLs. Our study paves the way to comprehend trait pleiotropy and functional interpretation of QTL and GWAS findings. All local gene co-expression identified here is available through a public database ( https://glcoex.unil.ch/ ).
PID Serval
serval:BIB_5AA3BA80411A
PMID
URL éditeur
Open Access
Oui
Date de création
2021-01-27T08:52:15.507Z
Date de création dans IRIS
2025-05-20T20:22:05Z
Fichier(s)![Vignette d'image]()
En cours de chargement...
Nom
34376650_BIB_5AA3BA80411A.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by/4.0
Taille
4 MB
Format
Adobe PDF
PID Serval
serval:BIB_5AA3BA80411A.P001
URN
urn:nbn:ch:serval-BIB_5AA3BA80411A0
Somme de contrôle
(MD5):80b6388f785cbcd122588dd23aeb1f15