Titre
Lack of prophylaxis before the onset of acute venous thromboembolism among hospitalized cancer patients: the SWIss Venous ThromboEmbolism Registry (SWIVTER).
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Kucher, N.
Auteure/Auteur
Spirk, D.
Auteure/Auteur
Baumgartner, I.
Auteure/Auteur
Mazzolai, L.
Auteure/Auteur
Korte, W.
Auteure/Auteur
Nobel, D.
Auteure/Auteur
Banyai, M.
Auteure/Auteur
Bounameaux, H.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1569-8041[electronic], 0923-7534[linking]
Statut éditorial
Publié
Date de publication
2010
Volume
21
Numéro
5
Première page
931
Dernière page/numéro d’article
935
Langue
anglais
Résumé
BACKGROUND: Venous thromboembolism (VTE) prophylaxis remains underutilized, particularly in cancer patients. We explored clinical predictors of prophylaxis in hospitalized cancer patients before the onset of acute VTE. METHODS: In the SWiss Venous ThromboEmbolism Registry, 257 cancer patients (61 +/- 15 years) with acute VTE and prior hospitalization for acute medical illness or surgery within 30 days (91% were at high risk with Geneva VTE risk score > or =3) were enrolled. RESULTS: Overall, 153 (60%) patients received prophylaxis (49% pharmacological and 21% mechanical) before the onset of acute VTE. Outpatient status at the time of VTE diagnosis [odds ratio (OR) 0.31, 95% confidence interval (CI) 0.18-0.53], ongoing chemotherapy (OR 0.51, 95% CI 0.31-0.85), and recent chemotherapy (OR 0.53, 95% CI 0.32-0.88) were univariately associated with the absence of VTE prophylaxis. In multivariate analysis, intensive care unit admission within 30 days (OR 7.02, 95% CI 2.38-20.64), prior deep vein thrombosis (OR 3.48, 95% CI 2.14-5.64), surgery within 30 days (OR 2.43, 95% CI 1.19-4.99), bed rest >3 days (OR 2.02, 95% CI 1.08-3.78), and outpatient status (OR 0.38, 95% CI 0.19-0.76) remained the only independent predictors of thromboprophylaxis. CONCLUSIONS: Although most hospitalized cancer patients were at high risk, 40% did not receive any prophylaxis before the onset of acute VTE. There is a need to improve thromboprophylaxis in cancer patients, particularly in the presence of recent or ongoing chemotherapy.
PID Serval
serval:BIB_76045116253C
PMID
Open Access
Oui
Date de création
2009-10-13T13:25:03.184Z
Date de création dans IRIS
2025-05-21T03:37:49Z
Fichier(s)![Vignette d'image]()
En cours de chargement...
Nom
REF.pdf
Version du manuscrit
published
Taille
108.47 KB
Format
Adobe PDF
PID Serval
serval:BIB_76045116253C.P001
URN
urn:nbn:ch:serval-BIB_76045116253C6
Somme de contrôle
(MD5):1b6001451834c9fcbdbf5401991f98e8