Titre
Precursor-product relationship between vitellogenin and the yolk proteins as derived from the complete sequence of a Xenopus vitellogenin gene.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Gerber-Huber, S.
Auteure/Auteur
Nardelli, D.
Auteure/Auteur
Haefliger, J.A.
Auteure/Auteur
Cooper, D.N.
Auteure/Auteur
Givel, F.
Auteure/Auteur
Germond, J.E.
Auteure/Auteur
Engel, J.
Auteure/Auteur
Green, N.M.
Auteure/Auteur
Wahli, W.
Auteure/Auteur
Liens vers les personnes
ISSN
0305-1048[print], 0305-1048[linking]
Statut éditorial
Publié
Date de publication
1987
Volume
15
Numéro
12
Première page
4737
Dernière page/numéro d’article
4760
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
In Xenopus laevis four estrogen-responsive genes are expressed simultaneously to produce vitellogenin, the precursor of the yolk proteins. One of these four genes, the gene A2, was sequenced completely, as well as cDNAs representing 75% of the coding region of the gene. From this data the exon-intron structure of the gene was established, revealing 35 exons that give a transcript of 5,619 bp without the poly A-tail. This A2 transcript encodes a vitellogenin of 1,807 amino acids, whose structure is discussed with respect to its function. At the nucleic acid as well as at the protein level no extensive homologies with any sequences other than vitellogenin were observed. Comparison of the amino acid sequence of the vitellogenin A2 molecule with biochemical data obtained from the different yolk proteins allowed us to localize the cleavage products on the vitellogenin precursor as follows: NH2 - lipovitellin I - phosvitin (or phosvette II - phosvette I) - lipovitellin II - COOH.
Sujets
PID Serval
serval:BIB_337B931BB904
PMID
Date de création
2008-01-24T15:04:12.738Z
Date de création dans IRIS
2025-05-20T16:26:32Z