Titre
Milestones in tumor vascularization and its therapeutic targeting.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
De Palma, M.
Auteure/Auteur
Hanahan, D.
Auteure/Auteur
Liens vers les unités
ISSN
2662-1347
Statut éditorial
Publié
Date de publication
2024-06
Volume
5
Numéro
6
Première page
827
Dernière page/numéro d’article
843
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Review ; Historical Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
Research into the mechanisms and manifestations of solid tumor vascularization was launched more than 50 years ago with the proposition and experimental demonstrations that angiogenesis is instrumental for tumor growth and was, therefore, a promising therapeutic target. The biological knowledge and therapeutic insights forthcoming have been remarkable, punctuated by new concepts, many of which were not foreseen in the early decades. This article presents a perspective on tumor vascularization and its therapeutic targeting but does not portray a historical timeline. Rather, we highlight eight conceptual milestones, integrating initial discoveries and recent progress and posing open questions for the future.
PID Serval
serval:BIB_A74D83B9B663
PMID
Date de création
2024-07-25T13:26:16.058Z
Date de création dans IRIS
2025-05-20T22:42:02Z