Titre
18F- FDG PET/CT-derived parameters predict clinical stage and prognosis of esophageal cancer.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Mantziari, S.
Auteure/Auteur
Pomoni, A.
Auteure/Auteur
Prior, J.O.
Auteure/Auteur
Winiker, M.
Auteure/Auteur
Allemann, P.
Auteure/Auteur
Demartines, N.
Auteure/Auteur
Schäfer, M.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1471-2342
Statut éditorial
Publié
Date de publication
2020-01-22
Volume
20
Numéro
1
Première page
7
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Résumé
Although <sup>18</sup> F- FDG PET/CT is validated in baseline workup of esophageal cancer to detect distant metastases, it remains underused in assessing local staging and biology of the primary tumor. This study aimed to evaluate the association between <sup>18</sup> F- FDG PET/CT-derived parameters of esophageal cancer, and its clinico-pathological features and prognosis.
All patients (n = 86) with esophageal adenocarcinoma or squamous cell cancer operated between 2005 and 2014 were analyzed. Linear regression was used to identify clinico-pathologic features of esophageal cancer associated with the tumor's maximal Standardized Uptake Value (SUV <sub>max</sub> ), Total Lesion Glycolysis (TLG) and Metabolic Tumor Volume (MTV). ROC curve analysis was performed to precise the optimal cutoff of each variable associated with a locally advanced (cT3/4) status, long-term survival and recurrence. Kaplan Meier curves and Cox regression were used for survival analyses.
High baseline SUV <sub>max</sub> was associated with cT3/4 status and middle-third tumor location, TLG with a cT3/4 and cN+ status, whereas MTV only with active smoking. A cT3/4 status was significantly predicted by a SUV <sub>max</sub> > 8.25 g/mL (p < 0.001), TLG > 41.7 (p < 0.001) and MTV > 10.70 cm <sup>3</sup> (p < 0.01) whereas a SUV <sub>max</sub> > 12.7 g/mL was associated with an early tumor recurrence and a poor disease-free survival (median 13 versus 56 months, p = 0.030), particularly in squamous cell cancer.
Baseline <sup>18</sup> F- FDG PET/CT has a high predictive value of preoperative cT stage, as its parameters SUV <sub>max</sub> , TLG and MTV can predict a locally advanced tumor with high accuracy. A SUV <sub>max</sub> > 12.7 g/mL may herald early tumor recurrence and poor disease-free survival.
All patients (n = 86) with esophageal adenocarcinoma or squamous cell cancer operated between 2005 and 2014 were analyzed. Linear regression was used to identify clinico-pathologic features of esophageal cancer associated with the tumor's maximal Standardized Uptake Value (SUV <sub>max</sub> ), Total Lesion Glycolysis (TLG) and Metabolic Tumor Volume (MTV). ROC curve analysis was performed to precise the optimal cutoff of each variable associated with a locally advanced (cT3/4) status, long-term survival and recurrence. Kaplan Meier curves and Cox regression were used for survival analyses.
High baseline SUV <sub>max</sub> was associated with cT3/4 status and middle-third tumor location, TLG with a cT3/4 and cN+ status, whereas MTV only with active smoking. A cT3/4 status was significantly predicted by a SUV <sub>max</sub> > 8.25 g/mL (p < 0.001), TLG > 41.7 (p < 0.001) and MTV > 10.70 cm <sup>3</sup> (p < 0.01) whereas a SUV <sub>max</sub> > 12.7 g/mL was associated with an early tumor recurrence and a poor disease-free survival (median 13 versus 56 months, p = 0.030), particularly in squamous cell cancer.
Baseline <sup>18</sup> F- FDG PET/CT has a high predictive value of preoperative cT stage, as its parameters SUV <sub>max</sub> , TLG and MTV can predict a locally advanced tumor with high accuracy. A SUV <sub>max</sub> > 12.7 g/mL may herald early tumor recurrence and poor disease-free survival.
PID Serval
serval:BIB_268491541B6B
PMID
Date de création
2020-01-29T16:05:07.939Z
Date de création dans IRIS
2025-05-20T18:16:54Z
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Nom
31969127_BIB_268491541B6B.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by/4.0
Taille
943.16 KB
Format
Adobe PDF
PID Serval
serval:BIB_268491541B6B.P001
URN
urn:nbn:ch:serval-BIB_268491541B6B7
Somme de contrôle
(MD5):9e49826941d74d038dd05eb8968039d3